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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Prevalence and associated factors of pulmonary hypertension in Kenyan children with adenoid or adenotonsillar hypertrophy
International Journal of Pediatric Otorhinolaryngology, Volume 78, No. 8, Year 2014
Notification
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Description
Objectives: Adenotonsillar hypertrophy is a common condition in childhood, whose serious complications of pulmonary hypertension and cor pulmonale are devastating but local prevalence is unknown. This study determined the prevalence and associated factors of pulmonary hypertension in children with adenoid or adenotonsillar hypertrophy at Kenyatta National Hospital, Kenya. Methods: This was a cross sectional hospital based survey conducted among children below 12 years of age with clinical and radiological adenoid hypertrophy attending the ear, nose and throat (ENT) outpatient clinic and general pediatric wards. Doppler echocardiography was used to determine pulmonary hypertension defined as a mean pulmonary arterial pressure (mPAP) of ≥25. mm Hg using the Chemla equation. Children with mPAP of ≥25. mm Hg were compared to those with lower pressures and clinical and radiological factors associated with pulmonary hypertension determined using multivariate logistic regression analysis. Results: Of the 123 eligible children in the study, 27 had pulmonary hypertension giving a prevalence of 21.9% (95% CI 14.64%-29.27%). Independent factors associated with pulmonary hypertension included nasal obstruction (OR = 3.0 [95% CI 1.08-8.44] p= 0.035) and hyperactivity on history (OR = 0.2 [95% CI 0.07-0.59] p= 0.003) and adenoid-nasopharyngeal ratio (ANR) >0.825 on lateral neck radiography (OR = 5.0 [95% CI 1.01-24.37] p= 0.048). Conclusion: One in five children with adenoid or adenotonsillar hypertrophy had pulmonary hypertension with a 3-fold and 5-fold increased odds in those with nasal obstruction on history and ANR >0.825 on lateral neck radiography respectively and an 80% reduced odds in reportedly hyperactive children. © 2014 Elsevier Ireland Ltd.
Authors & Co-Authors
Marangu, Diana M.
Kenya, Nairobi
University of Nairobi
Jowi, Christine
Kenya, Nairobi
University of Nairobi
Aswani, Joyce M.
Kenya, Nairobi
University of Nairobi
Wambani, Sidika
Kenya, Nairobi
Kenyatta National Hospital
Nduati, Ruth W.
Kenya, Nairobi
University of Nairobi
Statistics
Citations: 14
Authors: 5
Affiliations: 2
Identifiers
Doi:
10.1016/j.ijporl.2014.06.002
ISSN:
01655876
e-ISSN:
18728464
Research Areas
Health System And Policy
Maternal And Child Health
Noncommunicable Diseases
Study Design
Cross Sectional Study
Study Approach
Quantitative
Study Locations
Kenya