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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Meropenem-clavulanic acid shows activity against Mycobacterium tuberculosis in vivo
Antimicrobial Agents and Chemotherapy, Volume 56, No. 6, Year 2012
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Description
The carbapenems imipenem and meropenem in combination with clavulanic acid reduced the bacterial burden in Mycobacterium tuberculosis-infected macrophages by 2 logs over 6 days. Despite poor stability in solution and a short half-life in rodents, treatment of chronically infected mice revealed significant reductions of bacterial burden in the lungs and spleens. Our results show that meropenem has activity in two in vivo systems, but stability and pharmacokinetics of long-term administration will offer significant challenges to clinical evaluation. Copyright © 2012, American Society for Microbiology. All Rights Reserved.
Authors & Co-Authors
England, Kathleen D.
United States, Bethesda
National Institutes of Health Nih
Boshoff, Helena Ingrid M.
United States, Bethesda
National Institutes of Health Nih
Arora, Kriti
United States, Bethesda
National Institutes of Health Nih
Weiner, Danielle M.
United States, Bethesda
National Institutes of Health Nih
Dayao, Emmanuel K.
United States, Bethesda
National Institutes of Health Nih
Schimel, Daniel M.
United States, Bethesda
National Institutes of Health Nih
Via, L. E.
United States, Bethesda
National Institutes of Health Nih
Barry, Clifton Earl
United States, Bethesda
National Institutes of Health Nih
Statistics
Citations: 85
Authors: 8
Affiliations: 1
Identifiers
Doi:
10.1128/AAC.05690-11
ISSN:
10986596