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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Visceral leishmaniasis unresponsive to antimonial drugs iii. successful treatment using a combination of sodium stibogluconate plus allopurinol
Transactions of the Royal Society of Tropical Medicine and Hygiene, Volume 79, No. 5, Year 1985
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Description
Five patients with long-standing visceral leishmaniasis who were unresponsive to sodium stibogluconate, 20 mg antimony/kg body-weight once or twice daily, were treated for 14 to 54 days with a combination of sodium stibogluconate at the same dose plus allopurinol at a dose of 20 mg/kg body-weight per day in three divided doses. This combination was safe and effective. Negative splenic aspirate smears were obtained from all patients within 19 days, and none has relapsed in at least 12 months of follow-up. © Oxford University Press.
Authors & Co-Authors
Chunge, Charles N.
Kenya, Nairobi
Kenya Medical Research Institute
Kenya, Nairobi
University of Nairobi
Gacmra, G.
Kenya, Nairobi
Kenya Medical Research Institute
Kenya, Nairobi
University of Nairobi
Muigai, Richard K.
Kenya, Nairobi
Kenya Medical Research Institute
Kenya, Nairobi
University of Nairobi
Wasunna, Kevin Monique A.
Kenya, Nairobi
Kenya Medical Research Institute
Rashid, Juma R.
Kenya, Nairobi
Kenya Medical Research Institute
Chulay, Jeffrey D.
Kenya, Nairobi
Kenya Medical Research Institute
United States, Silver Spring
Walter Reed Army Institute of Research
Anabwani, Gabriel Misango
Kenya, Nairobi
Kenya Medical Research Institute
Kenya
Army Medical Research Unit
Oster, Charles N.
Kenya, Nairobi
Kenya Medical Research Institute
Bryceson, Anthony D.M.
Kenya, Nairobi
Kenya Medical Research Institute
United Kingdom, London
Hospital for Tropical Diseases
Statistics
Citations: 91
Authors: 9
Affiliations: 5
Identifiers
Doi:
10.1016/0035-9203(85)90200-7
ISSN:
00359203
e-ISSN:
18783503
Study Design
Cohort Study