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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
agricultural and biological sciences
Preexisting infection with human T-cell lymphotropic virus type 2 neither exacerbates nor attenuates simian immunodeficiency virus SIVmac251 infection in macaques
Journal of Virology, Volume 84, No. 6, Year 2010
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Description
Coinfection with human T-cell lymphotropic virus type 2 (HTLV-2) and human immunodeficiency virus type 1 (HIV-1) has been reported to have either a slowed disease course or to have no effect on progression to AIDS. In this study, we generated a coinfection animal model and investigated whether HTLV-2 could persistently infect macaques, induce a T-cell response, and impact simian immunodeficiency virus SIVmac251-induced disease. We found that inoculation of irradiated HTLV-2-infected T cells into Indian rhesus macaques elicited humoral and T-cell responses to HTLV-2 antigens at both systemic and mucosal sites. Low levels of HTLV-2 provirus DNA were detected in the blood, lymphoid tissues, and gastrointestinal tracts of infected animals. Exposure of HTLV-2-infected or naïve macaques to SIVmac251 demonstrated comparable levels of SIVmac251 viral replication, similar rates of mucosal and peripheral CD4+ T-cell loss, and increased T-cell proliferation. Additionally, neither the magnitude nor the functional capacity of the SIV-specific T-cell-mediated immune response was different in HTLV-2/SIVmac251 coinfected animals versus SIVmac251 singly infected controls. Thus, HTLV-2 targets mucosal sites, persists, and importantly does not exacerbate SIVmac251 infection. These data provide the impetus for the development of an attenuated HTLV-2-based vectored vaccine for HIV-1; this approach could elicit persistent mucosal immunity that may prevent HIV-1/SIVmac251 infection. Copyright © 2010, American Society for Microbiology. All Rights Reserved.
Authors & Co-Authors
Gordon, Shari N.
United States, Bethesda
National Institutes of Health Nih
Cecchinato, Valentina
United States, Bethesda
National Institutes of Health Nih
Fenizia, Claudio
United States, Bethesda
National Institutes of Health Nih
Lee, Tzong Hae
United States, San Francisco
Vitalant Research Institute
Zaffiri, Lorenzo
United States, Bethesda
National Institutes of Health Nih
Parks, Robyn Washington
United States, Bethesda
National Institutes of Health Nih
Héraud, Jean Michel
Madagascar, Antananarivo
Institut Pasteur de Madagascar
Ferrari, Maria Grazia
United States, Kensington
Advanced Bioscience Laboratories, Inc.
Venzon, David J.
United States, Bethesda
National Institutes of Health Nih
Mahieux, Renaud
France, Lyon
École Normale Supérieure de Lyon
Murphy, Edward Laurence
United States, San Francisco
University of California, San Francisco
United States, San Francisco
Vitalant Research Institute
Jacobson, Steven
United States, Bethesda
National Institute of Neurological Disorders and Stroke
Miller, Christopher J.
United States, Davis
California National Primate Research Center
Franchini, Genoveffa
United States, Bethesda
National Institutes of Health Nih
Statistics
Citations: 7
Authors: 14
Affiliations: 9
Identifiers
Doi:
10.1128/JVI.01655-09
ISSN:
0022538X
Research Areas
Genetics And Genomics
Infectious Diseases