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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
chemistry
Trans-placental transfer of thirteen perfluorinated compounds and relations with fetal thyroid hormones
Environmental Science and Technology, Volume 45, No. 17, Year 2011
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Description
While the results of animal studies have shown that perfluorinated compounds (PFCs) can modulate concentrations of thyroid hormones in blood, limited information is available on relationships between concentrations of PFCs in human blood serum and fetal thyroid hormones. The relationship between concentrations of PFCs in blood and fetal thyroid hormone concentrations or birth weight, and ratios of major PFCs between maternal and fetal serum were determined. Concentrations of PFCs were measured in blood serum of pregnant women (n = 44), fetal cord blood serum (n = 43) and breast milk (n = 35). Total concentrations of thyroxin (T4), triiodothyronin (T3) and thyroid stimulating hormone (TSH) in blood serum were also quantified. The ratios of major PFCs in maternal versus fetal serum were 1:1.93, 1.02, 0.72, and 0.48 for perfluorotridecanoic acid (PFTrDA), perfluorooctanoic acid (PFOA), perfluorohexane sulfonate (PFHxS), and perfluorooctane sulfonate (PFOS), respectively. Fetal PFOS, PFOA, PFTrDA and maternal PFTrDA were correlated with fetal total T4 concentrations, but after adjusting for major covariates, most of the relationships were no longer statistically significant. However, the significant negative correlations between maternal PFOS and fetal T3, and maternal PFTrDA and fetal T4 and T3 remained. Since thyroid hormones are crucial in the early development of the fetus, its clinical implication should be evaluated. Given the observed trans-placental transfer of PFCs, efforts should be also made to elucidate the exposure sources among pregnant women. © 2011 American Chemical Society.
Authors & Co-Authors
Kim, Sunmi
South Korea, Seoul
Seoul National University
Choi, Kyungho
South Korea, Seoul
Seoul National University
Ji, Kyunghee
South Korea, Seoul
Seoul National University
Seo, Jihyeon
South Korea, Seoul
Seoul National University
Kho, Younglim
South Korea, Daejeon
Eulji University
Park, Jeongim
South Korea, Asan
Soonchunhyang University
Kim, Sungkyoon
South Korea, Seoul
Seoul National University
Park, Seokhwan
South Korea, Cheongju
Seowon University
Hwang, Incheol
South Korea, Asan
Soonchunhyang University
Jeon, Jongkwan
South Korea, Seoul
Seoul National University Hospital
Yang, Hyeran
South Korea, Seoul
Seoul Metropolitan Government
Giesy, John P.
Canada, Saskatoon
University of Saskatchewan
United States, East Lansing
Michigan State University
Hong Kong, Hong Kong
City University of Hong Kong
Saudi Arabia, Riyadh
College of Sciences
Statistics
Citations: 214
Authors: 12
Affiliations: 10
Identifiers
Doi:
10.1021/es202408a
ISSN:
0013936X
e-ISSN:
15205851
Research Areas
Maternal And Child Health
Participants Gender
Female