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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Discovery and characterization of potent thiazoles versus methicillin- and vancomycin-resistant Staphylococcus aureus
Journal of Medicinal Chemistry, Volume 57, No. 4, Year 2014
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Description
Methicillin- and vancomycin-resistant Staphylococcus aureus (MRSA and VRSA) infections are growing global health concerns. Structure-activity relationships of phenylthiazoles as a new antimicrobial class have been addressed. We present 10 thiazole derivatives that exhibit strong activity against 18 clinical strains of MRSA and VRSA with acceptable PK profile. Three derivatives revealed an advantage over vancomycin by rapidly eliminating MRSA growth within 6 h, and no derivatives are toxic to HeLa cells at 11 μg/mL. © 2014 American Chemical Society.
Authors & Co-Authors
Mohammad, Haroon T.
United States, West Lafayette
Purdue University College of Veterinary Medicine
Mayhoub, Abdelrahman S.
United States, West Lafayette
Purdue University College of Pharmacy
Egypt, Cairo
Faculty of Pharmacy
Ghafoor, Adil
United States, West Lafayette
Purdue University College of Veterinary Medicine
Soofi, Muhammad
United States, West Lafayette
Purdue University College of Veterinary Medicine
Alajlouni, Ruba A.
United States, West Lafayette
Purdue University College of Veterinary Medicine
Cushman, Mark S.
United States, West Lafayette
Purdue University College of Pharmacy
Seleem, Mohamed N.
United States, West Lafayette
Purdue University College of Veterinary Medicine
Statistics
Citations: 92
Authors: 7
Affiliations: 3
Identifiers
Doi:
10.1021/jm401905m
ISSN:
00222623
e-ISSN:
15204804
Research Areas
Environmental