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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
chemistry
Schiff base compounds constructed from pyrazole–acetamide: Synthesis, spectroscopic characterization, crystal structure, DFT, molecular docking and antioxidant activity
Journal of Molecular Structure, Volume 1295, Article 136637, Year 2024
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Description
Two new Schiff base compounds, namely N-(2-((4-(dimethylamino)benzylidene)amino)phenyl)-2-(5-methyl-1H-pyrazol-3-yl)acetamide (DBPA) and N-(2-((4-methoxybenzylidene)amino)phenyl)-2-(5-methyl-1H-pyrazol-3-yl)acetamide (MBPA), have been synthesized through the condensation of N-(2-aminophenyl)-2-(5-methyl-1H-pyrazol-3-yl)acetamide (A) with aromatic aldehydes. Their structures have been elucidated on the basis on spectral data (1H NMR, 13C NMR ESI-MS) and confirmed by a single-crystal X-ray diffraction analysis. Thus, the crystallographic studies showed that the analysis of the crystal packing of DBPA and MBPA revealed 1D and 2D supramolecular architectures, respectively, via various hydrogen bonding interactions. Moreover, the evaluation of compounds A, DBPA and MBPA for their antioxidant activity against DPPH and ABTS radical scavenging assay, and reduction potency assay has been undertaken. using quercetin, Trolox and catechin as standard references respectively. The results obtained showed that DBPA appeared more hydrogen radical donor while MBPA appeared more electron donor. The comparison of the activities of the studied three molecules was carried out using both DFT and molecular docking calculations. Furthermore, ADME/T calculations have been made in order to show that these compounds can be used as potent drugs. © 2023 Elsevier B.V.
Authors & Co-Authors
Al Ati, Gamal
Morocco, Rabat
Mohammed V University in Rabat
Chkirate, Karim
Morocco, Rabat
Mohammed V University in Rabat
El-Guourrami, Otman
Morocco, Rabat
Mohammed V University in Rabat
Chakchak, Hind
Morocco, Rabat
Centre National Pour la Recherche Scientifique et Technique
Tüzün, Burak
Turkey, Sivas
Cumhuriyet Üniversitesi
Mague, Joel T.
United States, New Orleans
Tulane University
Benzeid, Hanane
Morocco, Rabat
Mohammed V University in Rabat
Achour, Redouane
Morocco, Rabat
Mohammed V University in Rabat
Essassi, El Mokhtar
Morocco, Rabat
Mohammed V University in Rabat
Statistics
Citations: 4
Authors: 9
Affiliations: 4
Identifiers
Doi:
10.1016/j.molstruc.2023.136637
ISSN:
00222860