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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
A variant in the gene FUT9 is associated with susceptibility to placental malaria infection
Human Molecular Genetics, Volume 18, No. 16, Year 2009
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Description
Malaria in pregnancy forms a substantial part of the worldwide burden of malaria, with an estimated annual death toll of up to 200 000 infants, as well as increased maternal morbidity and mortality. Studies of genetic susceptibility to malaria have so far focused on infant malaria, with only a few studies investigating the genetic basis of placental malaria, focusing only on a limited number of candidate genes. The aim of this study therefore was to identify novel host genetic factors involved in placental malaria infection. To this end we carried out a nested case-control study on 180 Mozambican pregnant women with placental malaria infection, and 180 controls within an intervention trial of malaria prevention. We genotyped 880 SNPs in a set of 64 functionally related genes involved in glycosylation and innate immunity. A single nucleotide polymorphism (SNP) located in the gene FUT9 , rs3811070, was significantly associated with placental malaria infection (odds ratio = 2.31, permutation P-value=0.028). Haplotypic analysis revealed a similarly strong association of a common haplotype of four SNPs including rs3811070. FUT9 codes for a fucosyl-transferase that is catalyzing the last step in the biosynthesis of the Lewis-x antigen, which forms part of the Lewis blood group-related antigens. These results therefore suggest an involvement of this antigen in the pathogenesis of placental malaria infection. © The Author 2009. Published by Oxford University Press. All rights reserved.
Authors & Co-Authors
Sikora, Martin
Spain, Barcelona
Csic-upf - Instituto de Biologia Evolutiva Ibe
Ferrer-Admetlla, Anna
Spain, Barcelona
Csic-upf - Instituto de Biologia Evolutiva Ibe
Laayouni, Hafid
Spain, Barcelona
Csic-upf - Instituto de Biologia Evolutiva Ibe
Spain, Madrid
Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública
Menéndez, Clara
Spain, Barcelona
Instituto de Salud Global de Barcelona
Mozambique, Manhica
Centro de Investigação em Saúde de Manhiça Cism
Mayor, A. G.
Spain, Barcelona
Instituto de Salud Global de Barcelona
Mozambique, Manhica
Centro de Investigação em Saúde de Manhiça Cism
Bardají, Azucena
Spain, Barcelona
Instituto de Salud Global de Barcelona
Mozambique, Manhica
Centro de Investigação em Saúde de Manhiça Cism
Sigaúque, Betuel
Mozambique, Manhica
Centro de Investigação em Saúde de Manhiça Cism
Mandomando, Inácio M.
Mozambique, Manhica
Centro de Investigação em Saúde de Manhiça Cism
Alonso, Pedro Luís
Spain, Barcelona
Instituto de Salud Global de Barcelona
Mozambique, Manhica
Centro de Investigação em Saúde de Manhiça Cism
Bertranpetit, Jaume
Spain, Barcelona
Csic-upf - Instituto de Biologia Evolutiva Ibe
Spain, Madrid
Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública
Casals, Ferran
Spain, Barcelona
Csic-upf - Instituto de Biologia Evolutiva Ibe
Canada, Montreal
Chu Sainte-justine - le Centre Hospitalier Universitaire Mère-enfant
Statistics
Citations: 12
Authors: 11
Affiliations: 5
Identifiers
Doi:
10.1093/hmg/ddp240
ISSN:
09646906
e-ISSN:
14602083
Research Areas
Genetics And Genomics
Infectious Diseases
Maternal And Child Health
Sexual And Reproductive Health
Study Design
Randomised Control Trial
Case-Control Study
Participants Gender
Female