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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Tumor burden assessed by the maximum standardized uptake value and greatest diameter on FDG-PET predicts prognosis in untreated diffuse large B-cell lymphoma
Nuclear Medicine and Molecular Imaging, Volume 44, No. 1, Year 2010
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Description
Purpose: It is uncertain whether the tumor burden as assessed using FDG-PET has prognostic significance in newly diagnosed diffuse large B-cell lymphoma (DLBCL). The authors undertook this study to determine whether a parameter that reflects both FDG uptake magnitude and the greatest tumor diameter is a prognostic indicator in DLBCL. Materials and Methods: Forty-two DLBCL patients (age, 57.4±15.5 years; male/female=25/17; stage I/II/III/IV=5/ 17/10/10) who underwent FDG-PET before chemotherapy were enrolled. A lesion with the highest maximum standardized uptake value (MaxSUV) on the PET image was selected, and size-incorporated MaxSUV (SIMaxSUV) of mass was calculated as MaxSUV × greatest diameter (mm) on the transaxial PET image. Median follow-up duration was 20.0 months. Results: Twelve (28.6%=12/42) patients experienced disease progression, and 10 (23.8%=10/42) died during follow-up. Among six variables [Ann Arbor stage, %Ki-67 expression, International Prognostic Index (IPI), MaxSUV, greatest diameter, and SIMaxSUV] investigated, only SIMaxSUV was found to be a single determinant of progression-free and overall survivals by multivariate analyses (p<0.05). Conclusion: These results suggest that SIMaxSUV, a new FDG-PET parameter that incorporates FDG uptake magnitude and the greatest tumor diameter, may be a useful indicator of prognosis in untreated DLBCL. © Korean Society of Nuclear Medicine 2010.
Authors & Co-Authors
Nguyen, Xuan Canh
South Korea, Seongnam
Seoul National University Bundang Hospital
Viet Nam, Ho Chi Minh City
Cho Ray Hospital
Lee, Won Woo
South Korea, Seongnam
Seoul National University Bundang Hospital
South Korea, Seoul
Seoul National University
Amin, Amr Mohamed
South Korea, Seongnam
Seoul National University Bundang Hospital
Egypt, Giza
Cairo University
Eo, Jae Seon
South Korea, Seongnam
Seoul National University Bundang Hospital
Bang, Soo-mee
South Korea, Seongnam
Seoul National University Bundang Hospital
Lee, Jong Seok
South Korea, Seongnam
Seoul National University Bundang Hospital
Kim, Sang Eun
South Korea, Seongnam
Seoul National University Bundang Hospital
South Korea, Seoul
Seoul National University
Statistics
Citations: 13
Authors: 7
Affiliations: 4
Identifiers
Doi:
10.1007/s13139-009-0009-0
ISSN:
18693474
e-ISSN:
18693482
Research Areas
Cancer
Health System And Policy
Study Design
Cohort Study
Participants Gender
Male
Female