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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Genome scan for tourette disorder in affected-sibling-pair and multigenerational families
American Journal of Human Genetics, Volume 80, No. 2, Year 2007
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Description
Tourette disorder (TD) is a neuropsychiatric disorder with a complex mode of inheritance and is characterized by multiple waxing and waning motor and phonic tics. This article reports the results of the largest genetic linkage study yet undertaken for TD. The sample analyzed includes 238 nuclear families yielding 304 "independent" sibling pairs and 18 separate multigenerational families, for a total of 2,040 individuals. A whole-genome screen with the use of 390 microsatellite markers was completed. Analyses were completed using two diagnostic classifications: (1) only individuals with TD were included as affected and (2) individuals with either TD or chronic-tic (CT) disorder were included as affected. Strong evidence of linkage was observed for a region on chromosome 2p (- logP = 4.42, P = 3.8 × 10-5) in the analyses that included individuals with TD or CT disorder as affected. Results in several other regions also provide moderate evidence (- logP >2.0) of additional susceptibility loci for TD. © 2006 by The American Society of Human Genetics. All rights reserved.
Authors & Co-Authors
Pauls, David L.
United States, Boston
Massachusetts General Hospital
Cath, Daniëlle C.
Netherlands, Amsterdam
Amsterdam Umc - Vrije Universiteit Amsterdam
Heutink, Peter
Netherlands, Amsterdam
Amsterdam Umc - Vrije Universiteit Amsterdam
Grados, M.
United States, Baltimore
Johns Hopkins School of Medicine
Singer, H. S.
United States, Baltimore
Johns Hopkins School of Medicine
Walkup, J. T.
United States, Baltimore
Johns Hopkins School of Medicine
Illmann, C.
United States, Boston
Massachusetts General Hospital
Scharf, Jeremiah M.
United States, Boston
Massachusetts General Hospital
Santangelo, S.
United States, Boston
Massachusetts General Hospital
Stewart, S. Evelyn
United States, Boston
Massachusetts General Hospital
Platko, Jill V.
United States, Boston
Massachusetts General Hospital
Pauls, David L.
United States, Boston
Massachusetts General Hospital
Cox, Nancy Jean
United States, Chicago
The University of Chicago
Robertson, Mary May
United Kingdom, London
Ucl Queen Square Institute of Neurology
Service, Susan K.
United States, Los Angeles
David Geffen School of Medicine at Ucla
Keen-Kim, D.
United States, Los Angeles
David Geffen School of Medicine at Ucla
Sabatti, Chiara
United States, Los Angeles
David Geffen School of Medicine at Ucla
Luben, Robert N.
United States, Los Angeles
David Geffen School of Medicine at Ucla
Rouleau, Guy Armand
Canada, Montreal
University of Montreal
Rivière, Jean Baptiste
Canada, Montreal
University of Montreal
Chouinard, Sylvain
Canada, Montreal
University of Montreal
Richer, F.
Canada, Montreal
University of Montreal
Lesperance, P.
Canada, Montreal
University of Montreal
Dion, Y.
Canada, Montreal
University of Montreal
King, Robert Alan
United States, New Haven
Yale Child Study Center
Kidd, Judith R.
United States, New Haven
Yale Child Study Center
Pakstis, Andrew J.
United States, New Haven
Yale Child Study Center
Leckman, J. F.
United States, New Haven
Yale Child Study Center
Kidd, Kenneth K.
United States, New Haven
Yale Child Study Center
Gericke, Georges S.
South Africa, Pretoria
Tshwane University of Technology
Kurlan, Roger M.
United States, Rochester
University of Rochester School of Medicine and Dentistry
Como, Peter G.
United States, Rochester
University of Rochester School of Medicine and Dentistry
Palumbo, Donna R.
United States, Rochester
University of Rochester School of Medicine and Dentistry
Verkerk, A.
Netherlands, Rotterdam
Erasmus Universiteit Rotterdam
Oostra, Ben A.
Netherlands, Rotterdam
Erasmus Universiteit Rotterdam
McMahon, W.
United States, Salt Lake City
University of Utah School of Medicine
Leppert, Mark F.
United States, Salt Lake City
University of Utah School of Medicine
Coon, H.
United States, Salt Lake City
University of Utah School of Medicine
Mathews, Carol A.
United States, San Francisco
University of California, San Francisco
Sandor, P.
Canada, Toronto
University of Toronto
Barr, C. L.
Canada, Toronto
University of Toronto
Bétard, Christine
France, Evry
Centre National de Recherche en Génomique Humaine
Zélénika, Diana
France, Evry
Centre National de Recherche en Génomique Humaine
Statistics
Citations: 43
Authors: 43
Affiliations: 15
Identifiers
Doi:
10.1086/511052
ISSN:
00029297
Research Areas
Cancer
Genetics And Genomics