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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
IL-22 participates in an innate anti-HIV-1 host-resistance network through acute-phase protein induction
Journal of Immunology, Volume 178, No. 1, Year 2007
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Description
Certain individuals are resistant to HIV-1 infection, despite repeated exposure to the virus. Although protection against HIV-1 infection in a small proportion of Caucasian individuals is associated with mutant alleles of the CCR5 HIV-1 coreceptor, the molecular mechanism underlying resistance in repeatedly HIV-1-exposed, uninfected individuals (EU) is unclear. In this study, we performed complementary transcriptome and proteome analyses on peripheral blood T cells, and plasma or serum from EU, their HIV-1-infected sexual partners, and healthy controls, all expressing wild-type CCR5. We report that activated T cells from EU overproduce several proteins involved in the innate immunity response, principally those including high levels of peroxiredoxin II, a NK-enhancing factor possessing strong anti-HIV activity, and IL-22, a cytokine involved in the production of acute-phase proteins such as the acute-phase serrai amyloid A (A-SAA). Cell supernatants and serum levels of these proteins were upregulated in EU. Moreover, a specific biomarker for EU detected in plasma was identified as an 8.6-kDa A-SAA cleavage product. Incubation of in vitro-generated myeloid immature dendritic cells with A-SAA resulted in CCR5 phosphorylation, down-regulation of CCR5 expression, and strongly decreased susceptibility of these cells to in vitro infection with a primary HIV-1 isolate. Taken together, these results suggest new correlates of EU protection and identify a cascade involving IL-22 and the acute phase protein pathway that is associated with innate host resistance to HIV infection. Copyright © 2006 by The American Association of Immunologists, Inc.
Authors & Co-Authors
Missé, Dorothée A.
Unknown Affiliation
Yssel, Hans
France, Paris
Inserm
Trabattoni, Daria Lucia
Italy, Milan
Università Degli Studi Di Milano
Lo Caputo, Sergio
Italy, Florence
Azienda Sanitaria Di Firenze
Mazzotta, Francesco
Italy, Florence
Azienda Sanitaria Di Firenze
Pêne, Jérôme
France, Paris
Inserm
Gonzalez, J. P.
Unknown Affiliation
Clerici, Mario S.
Italy, Milan
Università Degli Studi Di Milano
Veas, Francisco
France, Saint-denis-la-plaine
Etablissement Français du Sang
Statistics
Citations: 102
Authors: 9
Affiliations: 4
Identifiers
Doi:
10.4049/jimmunol.178.1.407
ISSN:
00221767
Research Areas
Infectious Diseases
Sexual And Reproductive Health