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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Serologic evidence of arboviral infections among humans in Kenya
American Journal of Tropical Medicine and Hygiene, Volume 85, No. 1, Year 2011
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Description
Outbreaks of arthropod-borne viral infections occur periodically across Kenya. However, limited surveillance takes place during interepidemic periods. Using serum samples obtained from asymptomatic persons across Kenya in 2000-2004, we assessed (by indirect immunofluorescent assay) prevalence of IgG against yellow fever virus (YFV), West Nile virus (WNV), tick-borne encephalitis virus (TBEV), dengue virus serotypes 1-4 (DENV1-4), and chikungunya virus (CHIKV). Older persons on the Indian Ocean coast were more likely to be seropositive than children inland: YFV = 42% versus 6%, WNV = 29% versus 6%, TBEV = 16% versus 6%, DENV-1 = 63% versus 9%, DENV-2 = 67% versus 7%, DENV-3 = 55% versus 6%, DENV-4 = 44% versus 8%, and CHIKV = 37% versus 20%. Among inland samples, children in lowlands were more likely to be seropositive for CHIKV (42% versus 0%) than children in highlands. In Kenya, transmission of arboviral infection continues between known epidemics and remains common across the country. Copyright © 2011 by The American Society of Tropical Medicine and Hygiene.
Authors & Co-Authors
Sutherland, Laura J.
United States, Cleveland
Case School of Medicine
Cash, Ayla A.
United States, Cleveland
Case School of Medicine
Huang, Yan Jang Scott
United States, Galveston
The University of Texas Medical Branch at Galveston
Sang, Rosemary C.
Kenya, Nairobi
Kenya Medical Research Institute
Malhotra, Indu J.
United States, Cleveland
Case School of Medicine
Moormann, Ann M.
United States, Worcester
University of Massachusetts Chan Medical School
King, Christopher L.
United States, Cleveland
Case School of Medicine
Weaver, Scott C.
United States, Galveston
The University of Texas Medical Branch at Galveston
King, Charles Harding
United States, Cleveland
Case School of Medicine
LaBeaud, Angelle Désirée
United States, Oakland
Children's Hospital Oakland Research Institute
Statistics
Citations: 83
Authors: 10
Affiliations: 5
Identifiers
Doi:
10.4269/ajtmh.2011.10-0203
ISSN:
00029637
Research Areas
Health System And Policy
Infectious Diseases
Maternal And Child Health
Study Design
Cross Sectional Study
Study Locations
Kenya