Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Short report: Human schistosomiasis is associated with endotoxemia and toll-like receptor 2- and 4-bearing B cells
American Journal of Tropical Medicine and Hygiene, Volume 84, No. 2, Year 2011
Notification
URL copied to clipboard!
Description
Schistosomiasis is caused by parasitic trematodes. Individuals can accumulate hundreds of intravascular worms, which secrete a myriad of antigenic molecules into the bloodstream. Some of these molecules suppress immunity to microbial Toll-like receptor (TLR) ligands, such as lipopolysaccharides, which may increase host susceptibility to coinfecting pathogens. We show that schistosomiasis is associated with extremely high levels of endotoxemia as well as high mobility group 1, an endogenous inflammatory TLR ligand, in the absence of other coinfected pathogens. Circulating B cells express surface TLR2 and TLR4, reflecting systemic exposure to microbial ligands. Bacterial translocation may occur with schistosomal egg movement from the vascular to the gut and other routes, such as the skin during infection. Our report suggests that immunosuppressive schistosome antigens may have evolved to curb inflammatory responses to the high antigenic burden of translocated bacteria products and endogenous TLR ligands that arise during parasite exposure and inflammation. Copyright © 2011 by The American Society of Tropical Medicine and Hygiene.
Authors & Co-Authors
Onguru, Daniel O.
Unknown Affiliation
Liang, Yan Mei
Unknown Affiliation
Griffith, Qyana K.
Unknown Affiliation
Nikolajczyk, Barbara
Unknown Affiliation
Mwinzi, Pauline Ngina M.
Unknown Affiliation
Ganley-Leal, Lisa M.
Unknown Affiliation
Statistics
Citations: 54
Authors: 6
Affiliations: 3
Identifiers
Doi:
10.4269/ajtmh.2011.10-0397
ISSN:
00029637
Research Areas
Health System And Policy
Infectious Diseases