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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Risk of lymphoma and leukaemia after bacille Calmette-Guérin and smallpox vaccination: A Danish case-cohort study
Vaccine, Volume 27, No. 49, Year 2009
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Description
Vaccines may have non-specific effects as suggested mainly in mortality studies from low-income countries. The objective was to examine the effects of BCG and smallpox vaccinations on subsequent risk of lymphoma and leukaemia in a Danish population experiencing rapid out-phasing of these vaccines. In a background cohort (N = 47,622) from the Copenhagen School Health Records Register, cases of leukaemia (N = 20) and lymphoma (N = 51) were identified through the Danish Cancer Registry. The vaccination status of the cases was compared with the vaccination status of a 5% random sample (N = 2073) of the background cohort and analysed in a case-cohort design. BCG vaccination reduced the risk of lymphomas (HR = 0.49 (95% CI: 0.26-0.93)), whereas smallpox vaccination did not (HR = 1.32 (0.56-3.08)). With the small number of leukaemia cases, the analysis of leukaemia had limited power (BCG vaccination HR = 0.81 (0.31-2.16); smallpox vaccination HR=1.32 (0.49-3.53)). The present study with very reliable vaccine history information indicates a beneficial effect of BCG vaccination on the risk of lymphomas. © 2009 Elsevier Ltd. All rights reserved.
Authors & Co-Authors
Villumsen, Marie
Denmark, Copenhagen
Copenhagen University Hospital
Ghana, Accra
Indepth Network
SØrup, Signe
Denmark, Copenhagen
Copenhagen University Hospital
Ghana, Accra
Indepth Network
Jess, Tine
Denmark, Copenhagen
Copenhagen University Hospital
Ravn, Henrik
Ghana, Accra
Indepth Network
Baker, Jennifer L.
Denmark, Copenhagen
Copenhagen University Hospital
Benn, Christine Stabell
Ghana, Accra
Indepth Network
Sørensen, T. I. A.
Denmark, Copenhagen
Copenhagen University Hospital
Aaby, Peter
Ghana, Accra
Indepth Network
Roth, Adam Edvin
Ghana, Accra
Indepth Network
Sweden, Lund
Lunds Universitet
Statistics
Citations: 52
Authors: 9
Affiliations: 4
Identifiers
Doi:
10.1016/j.vaccine.2009.08.103
ISSN:
0264410X
Research Areas
Cancer
Study Design
Cross Sectional Study
Cohort Study
Study Approach
Quantitative