Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
The fat mass and obesity gene is linked to reduced verbal fluency in overweight and obese elderly men
Neurobiology of Aging, Volume 32, No. 6, Year 2011
Notification
URL copied to clipboard!
Description
Humans carrying the prevalent rs9939609 A allele of the fat mass and obesity-associated (FTO) gene are more susceptible to developing obesity than noncarries. Recently, polymorphisms in the FTO gene of elderly subjects have also been linked to a reduced volume in the frontal lobe as well as increased risk for incident Alzheimer disease. However, so far there is no evidence directly linking the FTO gene to functional cognitive processes. Here we examined whether the FTO rs9939609 A allele is associated with verbal fluency performance in 355 elderly men at the age of 82 years who have no clinically apparent cognitive impairment. Retrieval of verbal memory is a good surrogate measure reflecting frontal lobe functioning. Here we found that obese and overweight but not normal weight FTO A allele carriers showed a lower performance on verbal fluency than non-carriers (homozygous for rs9939609 T allele). This effect was not observed for a measure of general cognitive performance (i.e., Mini-Mental State Examination score), thereby indicating that the FTO gene primarily affects frontal lobe-dependent cognitive processes in elderly men. © 2011 Elsevier Inc.
Authors & Co-Authors
Benedict, Christian
Sweden, Uppsala
Uppsala Universitet
Jacobsson, Josefin A.
Sweden, Uppsala
Uppsala Universitet
Brooks, Samantha Jane
Sweden, Uppsala
Uppsala Universitet
Fredriksson, Robert
Sweden, Uppsala
Uppsala Universitet
Lannfelt, Lars L.
Sweden, Uppsala
Uppsala Universitet
Kilander, Lena
Sweden, Uppsala
Uppsala Universitet
Schiöth, Helgi Birgir
Sweden, Uppsala
Uppsala Universitet
Statistics
Citations: 42
Authors: 7
Affiliations: 1
Identifiers
Doi:
10.1016/j.neurobiolaging.2011.02.006
ISSN:
01974580
Research Areas
Genetics And Genomics
Noncommunicable Diseases
Participants Gender
Male