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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Distinct bone marrow-derived and tissue-resident macrophage lineages proliferate at key stages during inflammation
Nature Communications, Volume 4, Article 1886, Year 2013
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Description
The general paradigm is that monocytes are recruited to sites of inflammation and terminally differentiate into macrophages. There has been no demonstration of proliferation of peripherally-derived inflammatory macrophages under physiological conditions. Here we show that proliferation of both bone marrow-derived inflammatory and tissue-resident macrophage lineage branches is a key feature of the inflammatory process with major implications for the mechanisms underlying recovery from inflammation. Both macrophage lineage branches are dependent on M-CSF during inflammation, and thus the potential for therapeutic interventions is marked. Furthermore, these observations are independent of Th2 immunity. These studies indicate that the proliferation of distinct macrophage populations provides a general mechanism for macrophage expansion at key stages during inflammation, and separate control mechanisms are implicated. © 2013 Macmillan Publishers Limited. All rights reserved.
Authors & Co-Authors
Davies, Luke C.
United Kingdom, Cardiff
Cardiff University School of Medicine
Rosas, Marcela
United Kingdom, Cardiff
Cardiff University School of Medicine
Jenkins, Stephen J.
United Kingdom, Edinburgh
The University of Edinburgh
Liao, Chiate
United Kingdom, Cardiff
Cardiff University School of Medicine
Scurr, Martin J.
United Kingdom, Cardiff
Cardiff University School of Medicine
Brombacher, Frank
South Africa, Observatory
International Center for Genetic Engineering and Biotechnology Icgeb
South Africa, Cape Town
University of Cape Town
Fraser, Donald J.
United Kingdom, Cardiff
Cardiff University School of Medicine
Allen, Judith E.
United Kingdom, Edinburgh
The University of Edinburgh
Jones, Simon A.
United Kingdom, Cardiff
Cardiff University School of Medicine
Taylor, Philip Russel
United Kingdom, Cardiff
Cardiff University School of Medicine
Statistics
Citations: 291
Authors: 10
Affiliations: 4
Identifiers
Doi:
10.1038/ncomms2877
e-ISSN:
20411723