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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Subacute seizure incidence in thrombolysis-treated ischemic stroke patients
Neurocritical Care, Volume 16, No. 2, Year 2012
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Description
Background To assess the incidence of seizures in acute ischemic stroke patients treated with chemical (tPA) thrombolysis. Methods Retrospective study including all thrombolysis patients treated in Calgary between January 1, 2001, and October 31, 2006. Descriptive statistics and age/sexadjusted P values were calculated. Results Of 400 eligible patients (median age 74.0 years, range: 24-77), 16 (4%) developed post-stroke seizures: 10 (62.5%) within one week (early) and 6 (37.5%) after 1 week but within the hospital stay (late). Single-vessel anterior circulation involvement (93.8% vs. 87%, P = 0.34) and hemorrhage (37.5% vs. 20%, P = 0.15) were more common in those with compared to without seizures but did not reach statistical significance. Atrial fibrillation was more common in those with (56.3%) than without (36.1%) seizures (P = 0.04). Death during admission was more likely (P = 0.03) in those who sustained seizures (37.5%) compared to those without seizures (17.6%). Conclusions In this cohort of tPA-treated patients, poststroke seizures were associated with atrial fibrillation and early mortality. © 2012 Springer Science+Business Media, LLC.
Authors & Co-Authors
Couillard, Philippe L.
Canada, Calgary
University of Calgary
Almekhlafi, Mohammed A.
Canada, Calgary
University of Calgary
Saudi Arabia, Jeddah
King Abdulaziz University
Irvine, A.
Canada, Calgary
University of Calgary
Jetté, Nathalie J.
Canada, Calgary
University of Calgary
Pow, Jody
Canada, Calgary
University of Calgary
St.Germaine-Smith, Christine
Canada, Calgary
University of Calgary
Pillay, Neelan
Canada, Calgary
University of Calgary
Hill, Michael D.
Canada, Calgary
University of Calgary
Canada, Calgary
Cumming School of Medicine
Statistics
Citations: 30
Authors: 8
Affiliations: 3
Identifiers
Doi:
10.1007/s12028-011-9657-x
ISSN:
15416933
e-ISSN:
15560961
Research Areas
Health System And Policy
Noncommunicable Diseases
Study Design
Cross Sectional Study
Cohort Study
Study Approach
Quantitative