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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Prevalence and characterization of extended-spectrum β-lactamase-producing clinical Salmonella enterica isolates in Dakar, Senegal, from 1999 to 2009
Clinical Microbiology and Infection, Volume 20, No. 2, Year 2014
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Description
A total of 1623 clinical isolates of Salmonella belonging to 229 serotypes were received by the Senegalese Reference Center for Enterobacteria from January 1999 to December 2009. The most common serotypes were Enteritidis (19% of the isolates), Typhi (8%), Typhimurium (7%) and Kentucky (4%). A significant increase in the prevalence of resistance to amoxicillin (0.9% in 1999 to 11.1% in 2009) and nalidixic acid (0.9% in 1999 to 26.7% in 2009) was observed in non-typhoidal Salmonella serotypes. For critically important antibiotics, notably ciprofloxacin and extended-spectrum cephalosporins (ESCs), the rates of resistance were low: 0.3% and 0.5%, respectively. Seven ESC-resistant Salmonella strains and three additional ESC-resistant strains from Senegal (1990) and Mali (2007) were studied to identify the genetic basis of their antibiotic resistance. All ESC-resistant strains produced an extended-spectrum β-lactamase (ESBL). These were CTX-M-15 (n = 6; 2000-2008), SHV-12 (n = 3; 2000-2001) and SHV-2 (n = 1; 1990). A large IncHI2 ST1 pK29-like plasmid was found in six strains (three producing SHV-12 and three CTX-M-15), whereas IncN and IncF plasmids were found in three strains and one strain, respectively. The association of plasmid-mediated quinolone resistance (PMQR) genes qnrB1 and aac(6')-Ib-cr was found in four ESBL-producing strains, leading to decreased susceptibility and even full resistance to ciprofloxacin (MIC range 0.75-2 mg/L) despite the absence of mutations in the quinolone resistance-determining region (QRDR) of gyrA, gyrB, parC and parE. This association of ESBL and multiple PMQR mechanisms within the same strains is therefore a serious concern as it hampers the use of both ESCs and fluoroquinolones for severe Salmonella infections. © 2013 European Society of Clinical Microbiology and Infectious Diseases.
Authors & Co-Authors
Harrois, Dorothée
France, Paris
Institut Pasteur, Paris
Senegal, Dakar
Institut Pasteur de Dakar
Breurec, Sébastien
Senegal, Dakar
Institut Pasteur de Dakar
Central African Republic, Bangui
Institut Pasteur de Bangui
Seck, Abdoulaye
Senegal, Dakar
Institut Pasteur de Dakar
Delauné, Aurélia
France, Paris
Institut Pasteur, Paris
Le Hello, Simon
France, Paris
Institut Pasteur, Paris
Pardos de la Gandara, Maria
France, Paris
Institut Pasteur, Paris
Sontag, Lucile
France, Paris
Institut Pasteur, Paris
Perrier-Gros-Claude, Jean David
Senegal, Dakar
Institut Pasteur de Dakar
Sire, Jean Marie
Senegal, Dakar
Institut Pasteur de Dakar
Garin, Benoît
Senegal, Dakar
Institut Pasteur de Dakar
Madagascar, Antananarivo
Institut Pasteur de Madagascar
Weill, François Xavier
France, Paris
Institut Pasteur, Paris
Statistics
Citations: 54
Authors: 11
Affiliations: 4
Identifiers
Doi:
10.1111/1469-0691.12339
ISSN:
1198743X
e-ISSN:
14690691
Research Areas
Genetics And Genomics
Infectious Diseases
Study Design
Cross Sectional Study
Study Locations
Mali
Senegal