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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Prognosis of HIV-associated non-Hodgkin lymphoma in patients starting combination antiretroviral therapy
AIDS, Volume 23, No. 15, Year 2009
Notification
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Description
Objective: We examined survival and prognostic factors of patients who developed HIV-associated non-Hodgkin lymphoma (NHL) in the era of combination antiretroviral therapy (cART). Design and setting: Multicohort collaboration of 33 European cohorts. Methods: We included all cART-naive patients enrolled in cohorts participating in the Collaboration of Observational HIV Epidemiological Research Europe (COHERE) who were aged 16 years or older, started cART at some point after 1 January 1998 and developed NHL after 1 January 1998. Patients had to have a CD4 cell count after 1 January 1998 and one at diagnosis of the NHL. Survival and prognostic factors were estimated using Weibull models, with random effects accounting for heterogeneity between cohorts. Results: Of 67 659 patients who were followed up during 304 940 person-years, 1176 patients were diagnosed with NHL. Eight hundred and forty-seven patients (72%) from 22 cohorts met inclusion criteria. Survival at 1 year was 66% [95% confidence interval (CI) 63-70%] for systemic NHL (n = 763) and 54% (95% CI: 43-65%) for primary brain lymphoma (n = 84). Risk factors for death included low nadir CD4 cell counts and a history of injection drug use. Patients developing NHL on cART had an increased risk of death compared with patients who were cART naive at diagnosis. Conclusion: In the era of cART two-thirds of patients diagnosed with HIV-related systemic NHL survive for longer than 1 year after diagnosis. Survival is poorer in patients diagnosed with primary brain lymphoma. More advanced immunodeficiency is the dominant prognostic factor for mortality in patients with HIV-related NHL. © 2009 Wolters Kluwer Health | Lippincott Williams & Wilkins.
Authors & Co-Authors
Bohlius, Julia
Unknown Affiliation
Schmidlin, Kurt
Unknown Affiliation
Fätkenheuer, Gerd
Unknown Affiliation
May, Margaret T.
Unknown Affiliation
Mocroft, Amanda J.
Unknown Affiliation
Bonnet, Fabrice
Unknown Affiliation
Clifford, Gary M.
France, Lyon
Centre International de Recherche Sur le Cancer
Touloumi, Giota
Unknown Affiliation
Miró, José María ª.
Unknown Affiliation
Chêne, Geneviève
Unknown Affiliation
Lundgren, Jens Dilling
Unknown Affiliation
Egger, Matthias
Unknown Affiliation
Antinori, Andrea
Unknown Affiliation
Boué, François
Unknown Affiliation
Brockmeyer, Norbert Hermann
Unknown Affiliation
Casabona, Jordi
Unknown Affiliation
Ribera Santasusana, Josep María María
Unknown Affiliation
Dronda, Fernando
Unknown Affiliation
Obel, Niels
Unknown Affiliation
Fisher, Martin J.
Unknown Affiliation
Franceschi, Silvia F.
Unknown Affiliation
Gibb, Di M.
Unknown Affiliation
Le-Moing, Vincent
Unknown Affiliation
Nadal, David
Unknown Affiliation
Prins, Maria
Unknown Affiliation
Raffi, François
Unknown Affiliation
Roca, B.
Unknown Affiliation
Verbon, Annelies
Unknown Affiliation
Wolf, Timo
Unknown Affiliation
Fortuny, Clàudia
Unknown Affiliation
Chakraborty, Rana
Unknown Affiliation
Sterne, Jonathan A.C.
Unknown Affiliation
Zwahlen, Marcel
Unknown Affiliation
Kjaer, Jesper
Unknown Affiliation
Colin, Céline
Unknown Affiliation
Weller, Ian V.D.
United Kingdom, London
University College London
Ledergerber, Bruno
Unknown Affiliation
Warszawski, Josiane
Unknown Affiliation
Meyer, Laurence J.
Unknown Affiliation
Dabis, François
Unknown Affiliation
Krause, Murielle Mary
Unknown Affiliation
Goujard, Cécile D.Sign©cile
Unknown Affiliation
Leport, Catherine
Unknown Affiliation
Reiss, Peter
Unknown Affiliation
Porter, Kholoud
Unknown Affiliation
Dorrucci, Maria
Unknown Affiliation
Sabin, Caroline A.
Unknown Affiliation
del Amo, Julia
Unknown Affiliation
Thorne, Claire N.
Unknown Affiliation
Kirk, Ole
Unknown Affiliation
Staszewski, Schlomo
Unknown Affiliation
Almeda Ortega, Jesús
Unknown Affiliation
D'Arminio Monforte, Antonella D.
Unknown Affiliation
Ramos, José Tomás
Spain, Madrid
Madrid Pmtct Cohort
Battegay, Manuel
Unknown Affiliation
Mussini, Cristina
Unknown Affiliation
Tookey, Pat A.
Unknown Affiliation
Castagna, Antonella
Unknown Affiliation
de Wit, Stéphane
Unknown Affiliation
Torti, Carlo
Italy
Italian Master Cohort
Teira, Ramón M.
Unknown Affiliation
Garrido, Myriam
Unknown Affiliation
Dedes, Nikos
Unknown Affiliation
Phillips, Andrew N.
Unknown Affiliation
Furrer, Hansjakob Jackob
Unknown Affiliation
Newell, Marie Louise
Unknown Affiliation
Telenti, Amalio
Unknown Affiliation
Pantazis, Nikos
Unknown Affiliation
Boufassa, Faroudy
Unknown Affiliation
Balestre, Eric
Unknown Affiliation
Gras, Luuk A.J.
Unknown Affiliation
Hill, Teresa
Unknown Affiliation
Judd, Ali M.
Unknown Affiliation
Duong, Trinh
Unknown Affiliation
Cozzi-Lepri, Alessandro
Unknown Affiliation
Corvasce, Stefano
Unknown Affiliation
Adorni, Fulvio
Unknown Affiliation
Ridolfo, Anna Lisa
Unknown Affiliation
Keiser, Olivia
Unknown Affiliation
Borghi, Vanni
Unknown Affiliation
Rickenbach, Martin
Unknown Affiliation
Statistics
Citations: 71
Authors: 81
Affiliations: 4
Identifiers
Doi:
10.1097/QAD.0b013e32832e531c
ISSN:
02699370
Research Areas
Genetics And Genomics
Infectious Diseases
Study Design
Cohort Study