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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Long Term Streptomycin Toxicity in the Treatment of Buruli Ulcer: Follow-up of Participants in the BURULICO Drug Trial
PLoS Neglected Tropical Diseases, Volume 8, No. 3, Article e2739, Year 2014
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Description
Background:Buruli Ulcer (BU) is a tropical infectious skin disease that is currently treated with 8 weeks of intramuscular streptomycin and oral rifampicin. As prolonged streptomycin administration can cause both oto- and nephrotoxicity, we evaluated its long term toxicity by following-up former BU patients that had received either 4 or 8 weeks of streptomycin in addition to other drugs between 2006 and 2008, in the context of a randomized controlled trial.Methods:Former patients were retrieved in 2012, and oto- and nephrotoxicity were determined by audiometry and serum creatinine levels. Data were compared with baseline and week 8 measurements during the drug trial.Results:Of the total of 151 former patients, 127 (84%) were retrieved. Ototoxicity was present in 29% of adults and 25% of children. Adults in the 8 week streptomycin group had significantly higher hearing thresholds in all frequencies at long term follow-up, and these differences were most prominent in the high frequencies. In children, no differences between the two treatment arms were found. Nephrotoxicity that had been detected in 14% of adults and in 13% of children during treatment, was present in only 2.4% of patients at long term follow-up.Conclusions:Prolonged streptomycin administration in the adult study subjects caused significant persistent hearing loss, especially in the high frequency range. Nephrotoxicity was also present in both adults and children but appeared to be transient. Streptomycin should be given with caution especially in patients aged 16 or older, and in individuals with concurrent risks for renal dysfunction or hearing loss. © 2014 Klis et al.
Authors & Co-Authors
Klis, Sandor Adrian
Netherlands, Groningen
Universitair Medisch Centrum Groningen
Stienstra, Ymkje
Netherlands, Groningen
Universitair Medisch Centrum Groningen
Phillips, Richard Odame
Ghana, Kumasi
Komfo Anokye Teaching Hospital
Abass, Kabiru Mohammed
Ghana, Agogo
Agogo Presbyterian Hospital
Tuah, Wilson
Ghana, Toase
Nkawie-toase Government Hospital
Van Derwerf, Tjip S.
Netherlands, Groningen
Universitair Medisch Centrum Groningen
Statistics
Citations: 57
Authors: 6
Affiliations: 4
Identifiers
Doi:
10.1371/journal.pntd.0002739
ISSN:
19352727
e-ISSN:
19352735
Research Areas
Disability
Health System And Policy
Maternal And Child Health
Study Design
Cohort Study
Study Approach
Quantitative