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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Vagal stimulation, through its nicotinic action, limits infarct size and the inflammatory response to myocardial Ischemia and reperfusion
Journal of Cardiovascular Pharmacology, Volume 58, No. 5, Year 2011
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Description
Vagal activity has protective effects in ischemic heart disease. We tested whether vagal stimulation (VS) could modulate the inflammatory reaction, a major determinant of cardiac injury after ischemia/reperfusion. Four groups of male rats underwent myocardial ischemia (30 minutes) and reperfusion (24 hours). One group underwent VS (40 minutes), 1 VS plus atrial pacing (VS + Pacing), and 1 VS plus nicotinic inhibition by mecamylamine (VS + MEC). After 24 hours, the area at risk, infarct size, inflammation parameters, and apoptosis were quantified. Infarct size was reduced in all VS-treated rats (controls, 53 ± 18%; VS, 6.5 ± 3%; VS + Pacing, 23 ± 6%; VS + MEC, 33 ± 9%; P < 0.005 vs. controls). The infarct size in the VS + MEC group was larger than that in VS-treated animals, despite similar heart rate, suggesting partial loss of protection. The number of macrophages, neutrophils, and apoptotic cells in the area at risk and the plasma cytokines levels were significantly reduced in all VS-treated animals. In conclusion, VS decreases infarct size and inflammatory markers during ischemia/reperfusion independent of the heart rate. The anti-inflammatory and antiapoptotic properties of the nicotinic pathway are the primary underlying mechanism. The vagally mediated modulation of inflammatory responses may prove valuable in the clinical management of acute coronary syndromes and of heart failure. Copyright © 2011 by Lippincott Williams & Wilkins.
Authors & Co-Authors
Calvillo, Laura
Italy, Milan
Irccs Istituto Auxologico Italiano
Vanoli, Emilio
Italy, Pavia
Università Degli Studi Di Pavia
Italy, Pavia
Fondazione Irccs
Andreoli, Elisa
Italy, Pavia
Fondazione Irccs
Besana, Alessandra
Italy, Milan
Irccs Istituto Auxologico Italiano
Omodeo, Elisabetta
Italy, Milan
Ospedale Luigi Sacco - Polo Universitario
Gnecchi, Massimiliano
Italy, Pavia
Università Degli Studi Di Pavia
Italy, Pavia
Fondazione Irccs Policlinico San Matteo
Zerbi, Pietro
Italy, Milan
Ospedale Luigi Sacco - Polo Universitario
Vago, Gianluca Luca
Italy, Milan
Ospedale Luigi Sacco - Polo Universitario
Busca, Giuseppe
Italy, Milan
Università Degli Studi Di Milano
Schwartz, Peter J.
Italy, Pavia
Università Degli Studi Di Pavia
Italy, Pavia
Fondazione Irccs
Italy, Pavia
Fondazione Irccs Policlinico San Matteo
South Africa, Cape Town
University of Cape Town
Saudi Arabia, Riyadh
College of Medicine
Statistics
Citations: 160
Authors: 10
Affiliations: 8
Identifiers
Doi:
10.1097/FJC.0b013e31822b7204
ISSN:
01602446
e-ISSN:
15334023
Research Areas
Cancer
Noncommunicable Diseases
Violence And Injury
Participants Gender
Male