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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Association of three polymorphisms selected from a genome-wide association study with coronary heart disease in the Tunisian population
Journal of Thrombosis and Thrombolysis, Volume 29, No. 1, Year 2010
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Description
Despite extensive exploration of many genes, strong evidence of a molecular genetic association with coronary heart disease (CHD) or myocardial infarction (MI) remains to be obtained. Recently, significant interest has emerged in mapping genetic susceptibility for complex traits through whole-genome studies association generating promoting data that will determine the genetic contribution to common human diseases such as coronary heart disease. The aim of the present case-control study including 324 healthy controls and 296 patients with coronary heart disease from Tunisia, was to assess relation between three polymorphisms previously reported to be strongly associated with coronary heart disease in the Welcome Trust Case Control Consortium (WTCCC) and the German myocardial infarction family studies: locus 9p21.3 (rs 1333049), locus 6q25.1 (rs6922269) and 2q36.3 (rs2943634). By single locus analysis, no differences in genotype distribution and allelic frequency were found between the two groups of study. The risk allele (C) for rs2943634 was less frequent among Tunisian population than in controls from the WTCCC and German studies (57% vs 65%). The three SNPs previously reported to be associated with CHD were not replicated in our small sample. © 2009 Springer Science+Business Media, LLC.
Authors & Co-Authors
Ghazouani, Lakhdar
Tunisia, Monastir
Faculté de Pharmacie de Monastir
Khalifa, Sonia Ben Hadj
Tunisia, Monastir
Faculté de Pharmacie de Monastir
Abboud, Nesrine
Tunisia, Monastir
Faculté de Pharmacie de Monastir
Perret, Claire
France, Paris
Hôpital Universitaire Pitié Salpêtrière
Nicaud, Viviane
France, Paris
Hôpital Universitaire Pitié Salpêtrière
Khalfallah, Ali Ben
Tunisia, Bizerte
Hôpital Menzel Bourguiba
Alamawi, Wassim Youssef
Bahrain, Manama
Arabian Gulf University
Cambien, François A.
France, Paris
Hôpital Universitaire Pitié Salpêtrière
Mahjoub, Touhami
Tunisia, Monastir
Faculté de Pharmacie de Monastir
Statistics
Citations: 9
Authors: 9
Affiliations: 4
Identifiers
Doi:
10.1007/s11239-009-0336-0
ISSN:
09295305
Research Areas
Genetics And Genomics
Noncommunicable Diseases
Study Design
Cross Sectional Study
Case-Control Study
Study Locations
Tunisia