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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
PROTECTIVE ACTIVITY OF VI CAPSULAR POLYSACCHARIDE VACCINE AGAINST TYPHOID FEVER
The Lancet, Volume 330, No. 8569, Year 1987
Notification
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Description
The protective efficacy against typhoid fever of a single intramuscular injection of 25 μg of the Vi capsular polysaccharide (CPS) was assessed in a randomised double-blind controlled trial. Vaccination of 11 384 children was followed by 21 months' surveillance. 47 blood-culture-proven cases of typhoid occurred in children who received meningococcal A + C CPS vaccine and 19 cases in those vaccinated with Vi CPS. Protective efficacy was 60% calculated from the day of vaccination and 64% from 6 weeks after vaccination. Surveillance also included 11 691 unvaccinated children; 173 cases occurred in this group. Protective efficacy in relation to the unvaccinated group was 77.4% and 81.0% after 21 months, calculated immediately and 6 weeks after vaccination, respectively. Vaccination was associated with minimum local side-effects, and an increase in anti-Vi antibodies occurred, as measured by radioimmunoassay and enzyme-linked immunosorbent assay. Antibody levels remained significantly raised at 6 and 12 months post vaccination. Vi CPS is thus a safe and effective means of typhoid vaccination. © 1987.
Authors & Co-Authors
Klugman, K. P.
South Africa, Johannesburg
University of the Witwatersrand
United Kingdom
National Institute for Tropical Diseases
South Africa, Pretoria
Sefako Makgatho Health Sciences University Smu
United Kingdom
Letaba Hospital
South Africa, Pretoria
University of Pretoria
France, Lyon
Institut Mérieux
United States, Bethesda
National Institute of Child Health and Human Development Nichd
Koornhof, Hendrik J.
South Africa, Johannesburg
University of the Witwatersrand
United Kingdom
National Institute for Tropical Diseases
South Africa, Pretoria
Sefako Makgatho Health Sciences University Smu
United Kingdom
Letaba Hospital
South Africa, Pretoria
University of Pretoria
France, Lyon
Institut Mérieux
United States, Bethesda
National Institute of Child Health and Human Development Nichd
Schneerson, R.
South Africa, Johannesburg
University of the Witwatersrand
United Kingdom
National Institute for Tropical Diseases
South Africa, Pretoria
Sefako Makgatho Health Sciences University Smu
United Kingdom
Letaba Hospital
South Africa, Pretoria
University of Pretoria
France, Lyon
Institut Mérieux
United States, Bethesda
National Institute of Child Health and Human Development Nichd
Cadoz, Michel
South Africa, Johannesburg
University of the Witwatersrand
United Kingdom
National Institute for Tropical Diseases
South Africa, Pretoria
Sefako Makgatho Health Sciences University Smu
United Kingdom
Letaba Hospital
South Africa, Pretoria
University of Pretoria
France, Lyon
Institut Mérieux
United States, Bethesda
National Institute of Child Health and Human Development Nichd
Gilbertson, Ian T.
South Africa, Johannesburg
University of the Witwatersrand
United Kingdom
National Institute for Tropical Diseases
South Africa, Pretoria
Sefako Makgatho Health Sciences University Smu
United Kingdom
Letaba Hospital
South Africa, Pretoria
University of Pretoria
France, Lyon
Institut Mérieux
United States, Bethesda
National Institute of Child Health and Human Development Nichd
Robbins, John B.
South Africa, Johannesburg
University of the Witwatersrand
United Kingdom
National Institute for Tropical Diseases
South Africa, Pretoria
Sefako Makgatho Health Sciences University Smu
United Kingdom
Letaba Hospital
South Africa, Pretoria
University of Pretoria
France, Lyon
Institut Mérieux
United States, Bethesda
National Institute of Child Health and Human Development Nichd
Schulz, Dominique
South Africa, Johannesburg
University of the Witwatersrand
United Kingdom
National Institute for Tropical Diseases
South Africa, Pretoria
Sefako Makgatho Health Sciences University Smu
United Kingdom
Letaba Hospital
South Africa, Pretoria
University of Pretoria
France, Lyon
Institut Mérieux
United States, Bethesda
National Institute of Child Health and Human Development Nichd
Armand, Jacques
South Africa, Johannesburg
University of the Witwatersrand
United Kingdom
National Institute for Tropical Diseases
South Africa, Pretoria
Sefako Makgatho Health Sciences University Smu
United Kingdom
Letaba Hospital
South Africa, Pretoria
University of Pretoria
France, Lyon
Institut Mérieux
United States, Bethesda
National Institute of Child Health and Human Development Nichd
Statistics
Citations: 283
Authors: 8
Affiliations: 7
Identifiers
Doi:
10.1016/S0140-6736(87)91316-X
ISSN:
01406736
Research Areas
Disability
Infectious Diseases
Maternal And Child Health