Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
pharmacology, toxicology and pharmaceutics
Neuropharmacological screening of Diospyros mespiliformis in mice
Journal of Ethnopharmacology, Volume 83, No. 1-2, Year 2002
Notification
URL copied to clipboard!
Description
The neuropharmacological activities of the aqueous extract of Diospyros mespiliformis stem bark were screened in mice. The extracts effect on pentobarbital-induced sleeping time, pentylenetetrazole induced seizure, spontaneous motor activity (SMA), exploratory behaviour, and rota-rod performance (motor coordination) were evaluated. The extract (100 and 200 mg/kg p.o.) produced a significant (P<0.05) prolongation of pentobarbital-induced sleeping time, and reduced the SMA and exploratory behaviour. The extract prolonged onset of the phases of seizure activity but did not protect mice against lethality induced by pentylenetetrazole. It also failed to affect the motor coordination test. These results suggest that the extract contained an agent with neuropharmacological activity that may be sedative in nature. © 2002 Elsevier Science Ireland Ltd. All rights reserved.
Authors & Co-Authors
Adzu, Bulus B.
Nigeria, Garki
National Institute for Pharmaceutical Research and Development, Nigeria
Amos, S.
Nigeria, Garki
National Institute for Pharmaceutical Research and Development, Nigeria
Muazzam, I.
Nigeria, Garki
National Institute for Pharmaceutical Research and Development, Nigeria
Inyang, Uford S.
Nigeria, Garki
National Institute for Pharmaceutical Research and Development, Nigeria
Gamaniel, Karniyus Shingu
Nigeria, Garki
National Institute for Pharmaceutical Research and Development, Nigeria
Statistics
Citations: 39
Authors: 5
Affiliations: 1
Identifiers
Doi:
10.1016/S0378-8741(02)00249-0
ISSN:
03788741
Study Design
Exploratory Study