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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
agricultural and biological sciences
Proliferative capacity of epitope-specific CD8 T-cell responses is inversely related to viral load in chronic human immunodeficiency virus type 1 infection
Journal of Virology, Volume 81, No. 1, Year 2007
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Description
The relationship between the function of human immunodeficiency virus (HIV)-specific CD8 T-cell responses and viral load has not been defined. In this study, we used a panel of major histocompatibility complex class I tetramers to examine responses to frequently targeted CD8 T-cell epitopes in a large cohort of antiretroviral-therapy-naïve HIV type 1 clade C virus-infected persons in KwaZulu Natal, South Africa. In terms of effector functions of proliferation, cytokine production, and degranulation, only proliferation showed a significant correlation with viral load. This robust inverse relationship provides an important functional correlate of viral control relevant to both vaccine design and evaluation. Copyright © 2007, American Society for Microbiology. All Rights Reserved.
Authors & Co-Authors
Day, Cheryl Cheryl L.
United Kingdom, Oxford
Nuffield Department of Medicine
South Africa, Durban
University of Kwazulu-natal
United States, Boston
Massachusetts General Hospital
Kiepiela, Photini
South Africa, Durban
University of Kwazulu-natal
Leslie, Alasdair J.
United Kingdom, Oxford
Nuffield Department of Medicine
van der Stok, Mary
South Africa, Durban
University of Kwazulu-natal
Nair, Kriebashnie S.
South Africa, Durban
University of Kwazulu-natal
Ismail, Nasreen
South Africa, Durban
University of Kwazulu-natal
Honeyborne, Isobella
United Kingdom, Oxford
Nuffield Department of Medicine
Crawford, Hayley
United Kingdom, Oxford
Nuffield Department of Medicine
Coovadia, Hoosen Mahomed
South Africa, Durban
University of Kwazulu-natal
Goulder, Philip Jeremy Renshaw
United Kingdom, Oxford
Nuffield Department of Medicine
South Africa, Durban
University of Kwazulu-natal
United States, Boston
Massachusetts General Hospital
Walker, Bruce D.
South Africa, Durban
University of Kwazulu-natal
United States, Boston
Massachusetts General Hospital
United States, Chevy Chase
Howard Hughes Medical Institute
Klenerman, Paul
United Kingdom, Oxford
Nuffield Department of Medicine
Statistics
Citations: 103
Authors: 12
Affiliations: 4
Identifiers
Doi:
10.1128/JVI.01754-06
ISSN:
0022538X
Research Areas
Infectious Diseases
Study Design
Cohort Study
Study Locations
South Africa