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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
HIV type 1 transmission networks among men having sex with men and heterosexuals in Kenya
AIDS Research and Human Retroviruses, Volume 30, No. 2, Year 2014
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Description
We performed a molecular phylogenetic study on HIV-1 polymerase sequences of men who have sex with men (MSM) and heterosexual patient samples in Kenya to characterize any observed HIV-1 transmission networks. HIV-1 polymerase sequences were obtained from samples in Nairobi and coastal Kenya from 84 MSM, 226 other men, and 364 women from 2005 to 2010. Using Bayesian phylogenetics, we tested whether sequences clustered by sexual orientation and geographic location. In addition, we used trait diffusion analyses to identify significant epidemiological links and to quantify the number of transmissions between risk groups. Finally, we compared 84 MSM sequences with all HIV-1 sequences available online at GenBank. Significant clustering of sequences from MSM at both coastal Kenya and Nairobi was found, with evidence of HIV-1 transmission between both locations. Although a transmission pair between a coastal MSM and woman was confirmed, no significant HIV-1 transmission was evident between MSM and the comparison population for the predominant subtype A (60%). However, a weak but significant link was evident when studying all subtypes together. GenBank comparison did not reveal other important transmission links. Our data suggest infrequent intermingling of MSM and heterosexual HIV-1 epidemics in Kenya. © Mary Ann Liebert, Inc.
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC3910480/bin/Supp_Figure1.pdf
https://efashare.b-cdn.net/share/pmc/articles/PMC3910480/bin/Supp_Figure2.pdf
Authors & Co-Authors
Bezemer, Daniela O.
Netherlands, Amsterdam
Stichting Hiv Monitoring
Faria, Nuno R.
Belgium, Leuven
Ku Leuven
Hassan, Amin Shaban
Kenya, Kilifi
Centre for Geographic Medicine Research
Hamers, Raph L.
Netherlands, Amsterdam
Amsterdam Umc - University of Amsterdam
Mutua, Gaudensia Nzembi
Kenya, Nairobi
University of Nairobi
Anzala, Aggrey Omu
Kenya, Nairobi
University of Nairobi
Mandaliya, Kishor N.
Kenya, Mombasa
Coast Provincial General Hospital, Kenya
Cane, Patricia A.
United Kingdom, London
Public Health England
Berkley, James A.
Kenya, Kilifi
Centre for Geographic Medicine Research
United Kingdom, Oxford
Nuffield Department of Medicine
Rinke de Wit, Tobias Floris
Netherlands, Amsterdam
Amsterdam Umc - University of Amsterdam
Wallis, Carole Lorraine
South Africa, Johannesburg
Lancet Laboratories
Graham, Susan Marie
Kenya, Kilifi
Centre for Geographic Medicine Research
United States, Seattle
University of Washington
Price, Matt A.
United States, New York
International Aids Vaccine Initiative
United States, San Francisco
University of California, San Francisco
Coutinho, Roel A.
Netherlands, Bilthoven
Rijksinstituut Voor Volksgezondheid en Milieu
Netherlands, Utrecht
University Medical Center Utrecht
Sanders, Eduard Joachim
Kenya, Kilifi
Centre for Geographic Medicine Research
United Kingdom, Oxford
Nuffield Department of Medicine
Statistics
Citations: 46
Authors: 15
Affiliations: 14
Identifiers
Doi:
10.1089/aid.2013.0171
ISSN:
08892229
e-ISSN:
19318405
Research Areas
Health System And Policy
Infectious Diseases
Sexual And Reproductive Health
Study Design
Cross Sectional Study
Study Locations
Kenya
Participants Gender
Male
Female