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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Clinical characteristics, treatment and outcome of childhood Burkitt's lymphoma at the Uganda Cancer Institute
Transactions of the Royal Society of Tropical Medicine and Hygiene, Volume 105, No. 12, Year 2011
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Description
Burkitt's lymphoma (BL) is a major cause of death among Ugandan children. We studied clinical characteristics and outcomes of childhood BL over time at the Uganda Cancer Institute (UCI). A total of 1217 children (766 boys, 451 girls, mean age 6.69 years) diagnosed with BL between 1985 and 2005 were included. There were no significant changes in the proportion of boys and girls diagnosed, or in mean age at diagnosis. Facial tumor (n= 945, 77.65%) and abdominal disease (n= 842, 69.19%) were the most common presentations. The proportion of children presenting with hepatic mass, malignant pleocytosis, and advanced-stage (stage C and D) BL increased during the study period (P<0.01). A total of 1085 children out of 1206 (89.97%) received at least one cycle of chemotherapy, and 832 of 1099 (75.71%) demonstrated objective response (i.e. complete or partial remission). The most common symptoms at BL diagnosis were fever (n= 621, 51.03%), anemia (n= 593, 48.73%), and weight loss (n= 588, 48.32%). Significant increases in the proportion of children with fever, and significant changes in the proportion of children with anemia, night sweats and severe infection were observed. HIV positivity was 3.87%, but no substantial differences in the proportion of HIV-positive children were observed. Mortality was not significantly different over time: it was similar in boys and girls, higher in older children (compared with younger ones), in those with advanced-stage BL, and HIV-positive children, but lower in children with facial tumors compared with other tumor presentations, and among those who received chemotherapy. © 2011 Royal Society of Tropical Medicine and Hygiene.
Authors & Co-Authors
Orem, Jackson
Uganda, Kampala
School of Medicine, Makerere University College of Health Sciences
Sweden, Stockholm
Karolinska Institutet
Mulumba, Yusuf
Uganda, Kampala
School of Medicine, Makerere University College of Health Sciences
Algeri, Sara
Italy, Milan
Università Degli Studi Di Milano-bicocca
Bellocco, Rino
Sweden, Stockholm
Karolinska Institutet
Italy, Milan
Università Degli Studi Di Milano-bicocca
Mangen, Fred Wabwire
Uganda, Kampala
Makerere University School of Public Health
Mbidde, Edward Katongole
Uganda, Kampala
School of Medicine, Makerere University College of Health Sciences
Uganda, Entebbe
Uganda Virus Research Institute
Weiderpass, Elisabete
Sweden, Stockholm
Karolinska Institutet
Norway, Oslo
Cancer Registry of Norway
Norway, Tromso
Uit Norges Arktiske Universitet
Statistics
Citations: 32
Authors: 7
Affiliations: 7
Identifiers
Doi:
10.1016/j.trstmh.2011.08.008
ISSN:
00359203
e-ISSN:
18783503
Research Areas
Cancer
Health System And Policy
Infectious Diseases
Maternal And Child Health
Study Locations
Uganda
Participants Gender
Male
Female