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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Pharmacokinetic properties and antitumor efficacy of the 5-fluorouracil loaded PEG-hydrogel
BMC Cancer, Volume 10, Article 211, Year 2010
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Description
Background: We have studied the in vitro and in vivo utility of polyethylene glycol (PEG)-hydrogels for the development of an anticancer drug 5-fluorouracil (5-FU) delivery system.Methods: A 5-FU-loaded PEG-hydrogel was implanted subcutaneously to evaluate the drug retention time and the anticancer effect. For the pharmacokinetic study, two groups of male rats were administered either an aqueous solution of 5-FU (control group)/or a 5-FU-loaded PEG-hydrogel (treated group) at a dose of 100 mg/kg. For the pharmacodynamic study, a human non-small-cell lung adenocarcinoma (NSCLC) cell line, A549 was inoculated to male nude mice with a cell density of 3 × 106. Once tumors start growing, the mice were injected with 5-FU/or 5-FU-loaded PEG-hydrogel once a week for 4 weeks. The growth of the tumors was monitored by measuring the tumor volume and calculating the tumor inhibition rate (IR) over the duration of the study.Results: In the pharmacokinetic study, the 5-FU-loaded PEG-hydrogel gave a mean residence time (MRT) of 8.0 h and the elimination half-life of 0.9 h; these values were 14- and 6-fold, respectively, longer than those for the free solution of 5-FU (p < 0.05). In the pharmacodynamic study, A549 tumor growth was significantly inhibited in the 5-FU-loaded PEG-hydrogel group in comparison to the untreated group beginning on Day 14 (p < 0.05-0.01). Moreover, the 5-FU-loaded PEG-hydrogel group had a significantly enhanced tumor IR (p < 0.05) compared to the free 5-FU drug treatment group.Conclusion: We suggest that 5-FU-loaded PEG-hydrogels could provide a useful tool for the development of an anticancer drug delivery system. © 2010 Yi et al; licensee BioMed Central Ltd.
Authors & Co-Authors
Yi, Hee
South Korea, Seoul
Konkuk University
Cho, Hee-jung
South Korea, Seoul
Konkuk University
Cho, Soo Min
South Korea, Seoul
Konkuk University
Lee, Dong-goo
South Korea, Seoul
Konkuk University
Abd El-Aty, A. M.
South Korea, Seoul
Konkuk University
Egypt, Giza
Faculty of Veterinary Medicine
Yoon, So Jeong
South Korea, Anyang
Sunbio Inc
Bae, Gun Won
South Korea, Anyang
Sunbio Inc
Nho, Kwang
South Korea, Anyang
Sunbio Inc
Kim, Bokyung
South Korea, Seoul
Konkuk University Graduate School of Medicine
Lee, Chiho
South Korea, Seoul
Konkuk University
Kim, Jin-suk
South Korea, Seoul
Konkuk University
Bartlett, Michael G.
United States, Athens
University of Georgia
Shin, Ho-chul
South Korea, Seoul
Konkuk University
Statistics
Citations: 13
Authors: 13
Affiliations: 5
Identifiers
Doi:
10.1186/1471-2407-10-211
e-ISSN:
14712407
Research Areas
Cancer
Study Design
Randomised Control Trial
Participants Gender
Male