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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Incidence of malaria among mosquito collectors conducting human landing catches in western kenya
American Journal of Tropical Medicine and Hygiene, Volume 88, No. 2, Year 2013
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Description
The human landing catch (HLC) has long been the gold standard for estimating malaria transmission by mosquitoes, but has come under scrutiny because of ethical concerns of exposing collectors to infectious bites. We estimated the incidence of Plasmodium falciparum malaria infection in a cohort of 152 persons conducting HLCs and compared it with that of 147 non-collectors in western Kenya. Participants were presumptively cleared of malaria with Coartem™ (artemether-lumefantrine) and tested for malaria every 2 weeks for 12 weeks. The HLC collections were conducted four nights per week for six weeks. Collectors were provided chemoprophylaxis with Malarone™ (atovaquone-proguanil) during the six weeks of HLC activities and one week after HLC activities were completed. The incidence of malaria was 96.6% lower in collectors than in non-collectors (hazard ratio = 0.034, P < 0.0001). Therefore, with proper prophylaxis, concern about increased risk of malaria among collectors should not be an impediment to conducting HLC studies. Copyright © 2013 by The American Society of Tropical Medicine and Hygiene.
Authors & Co-Authors
Gimnig, John E.
United States, Atlanta
Centers for Disease Control and Prevention
Walker, Edward D.
United States, East Lansing
Michigan State University
Otieno, Peter O.
United States, Atlanta
Centers for Disease Control and Prevention
Kosgei, Jackline
United States, Atlanta
Centers for Disease Control and Prevention
Olang, George B.
United States, Atlanta
Centers for Disease Control and Prevention
Ombok, Maurice Ochieng
United States, Atlanta
Centers for Disease Control and Prevention
Williamson, John Michael
United States, Atlanta
Centers for Disease Control and Prevention
Marwanga, Doris
United States, Atlanta
Centers for Disease Control and Prevention
Abong'o, Daisy
United States, Atlanta
Centers for Disease Control and Prevention
Desai, Meghna R.
United States, Atlanta
Centers for Disease Control and Prevention
Kariuki, Simon K.
United States, Atlanta
Centers for Disease Control and Prevention
Hamel, Mary J.
United States, Atlanta
Centers for Disease Control and Prevention
Lobo, Neil Francis
United States, Notre Dame
University of Notre Dame
Vulule, John M.
Kenya, Nairobi
Kenya Medical Research Institute
Bayoh, Mohamed Nabie
United States, Atlanta
Centers for Disease Control and Prevention
Statistics
Citations: 90
Authors: 15
Affiliations: 4
Identifiers
Doi:
10.4269/ajtmh.2012.12-0209
ISSN:
00029637
Research Areas
Environmental
Health System And Policy
Infectious Diseases
Study Design
Cohort Study
Study Locations
Kenya