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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Endemic african kaposi's sarcoma is not associated with immunodeficiency
International Journal of Cancer, Volume 36, No. 1, Year 1985
Notification
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Description
Twenty‐seven histologically confirmed Kaposi sarcoma (KS) patients resident in the Kivu Lake area of eastern Zaire were examined for immune competence. Only KS cases of the endemic African type have been observed in this high‐incidence area. The median duration of the symptoms was 6 years and ranged from 1 to 38 years. Forty‐one controls matched for age, sex and tribe and unrelated to the KS patients were selected from the community. Thirteen additional controls were first‐degree relatives of the KS patients. No evidence of immune suppression among KS patients was found and there were no significant differences in the immune status between KS patients and controls. Total lymphocytes, B and T cells, and OKT4 + and OKT8 + cells varied within the normal range. Grouping of the KS patients in categories according to duration and disease extent did not reveal significant differences in their immune status. The number of KS patients reacting positively in a skin test to 5 recall antigens and I mitogen was similar that of controls, except in the case of candidin, to which a higher number of KS patients were negative. The serum levels of immunoglobulins, complement factors and circulating immune complexes were comparable in KS patients and controls. Indicators of inflammatory processes [white blood cells (WBC), complement‐reactive protein (CRP)] were positive in 27% of the KS patients. The prevalence and mean titer of antibody against cytomegalovirus (CMV), Epstein‐Barr virus (EBV), hepatitis B virus (HBV) and syphilis were similar in KS patients and in controls. Copyright © 1985 Wiley‐Liss, Inc., A Wiley Company
Authors & Co-Authors
Kestens, Luc L.
Belgium, Antwerpen
Prins Leopold Instituut Voor Tropische Geneeskunde
Melbye, Mads
Denmark, Aarhus
Aarhus Universitetshospital
Biggar, Robert John
United States, Rockville
National Cancer Institute Nci
Stevens, Willem J.M.K.
Belgium, Antwerpen
Universiteit Antwerpen
Piot, Peter K.
Belgium, Antwerpen
Prins Leopold Instituut Voor Tropische Geneeskunde
de Muynck, Aimé O.
Belgium, Antwerpen
Prins Leopold Instituut Voor Tropische Geneeskunde
Taelman, Henri
Belgium, Antwerpen
Prins Leopold Instituut Voor Tropische Geneeskunde
de Feyter, Marc
Congo
Fomulac Hospital
Paluku, Leopold
Congo
Fomulac Hospital
Gigase, Paul L.J.
Belgium, Antwerpen
Prins Leopold Instituut Voor Tropische Geneeskunde
Statistics
Citations: 87
Authors: 10
Affiliations: 5
Identifiers
Doi:
10.1002/ijc.2910360109
ISSN:
00207136
e-ISSN:
10970215
Research Areas
Cancer
Infectious Diseases
Study Design
Cross Sectional Study
Cohort Study