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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Frequency and genotype of human papillomavirus among Sudanese patients with head and neck tumours
ecancermedicalscience, Volume 6, No. 1, Article 282, Year 2012
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Description
Objectives: The aim of this study was to determine the frequency and genotype of human papillomavirus (HPV) infections in head and neck squamous cell carcinomas (HNSCCs) and benign head and neck tumours. Methodology: A retrospective study was performed on 150 samples of patients diagnosed with HNSCCs and 50 samples obtained from patients diagnosed with benign head and neck tumours. Tumour DNA was amplified using polymerase chain reaction (PCR) with HPV consensus and multiplex primers. Results: Six of the 150 (4%) HNSCCs were HPV positive. HPV16 was the most prevalent type, with single infections present in 3/6 (50%) cases, whereas HPV18 and HPV33 were detected in 2/6 (33%) and 1/6 (17%), respectively. HPV infections were detected in 3 (50%) cases of oral cavity and 3 (50%) cases of pharynx. Conclusions: There was a significant association between HPV infection and HNSCCs (P < 0.05). The present data support the importance of HPV infection in oral and larynx tumours. © the authors; licensee ecancermedicalscience.
Authors & Co-Authors
Ahmed, Hussain Gadelkarim
Saudi Arabia, Hail
University of Ha'il
Mustafa, Saadalnour Abusail
Sudan, Khartoum
University of Elneelain
Eltom, Faris Margani
Saudi Arabia
Tyba University
Babiker, Ali Yousef Yahia
Saudi Arabia, Buraidah
Al Qassim University
Statistics
Citations: 8
Authors: 4
Affiliations: 4
Identifiers
Doi:
10.3332/ecancer.2012.282
e-ISSN:
17546605
Research Areas
Cancer
Genetics And Genomics
Health System And Policy
Study Design
Cohort Study