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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Predictive factors of overall well-being using the EORTC QLQ-C15-PAL extracted from the EORTC QLQ-C30
Journal of Palliative Medicine, Volume 16, No. 4, Year 2013
Notification
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Description
Objective: The European Organization of Research and Treatment of Cancer (EORTC) Quality of Life Questionnaire - Core 15 Palliative (EORTC QLQ-C15-PAL) was developed to assess quality of life (QOL) for the palliative cancer population to decrease patient burden. The purpose of this study was to compare predictive factors for well-being in the QLQ-C15-PAL extracted from the EORTC Quality of Life Questionnaire - Core 30 (QLQ-C30) with the QLQ-C30 itself. Methods and Materials: Patients with advanced cancer referred for treatment of bone metastases completed the QLQ-C30. Fifteen items from the QLQ-C15-PAL were extracted from the QLQ-C30. Univariate and multivariate analyses were used to determine predictive factors of the global QOL/health score in both tools. In the multivariate analyses, a p value of <0.003 indicated statistical significance. Results: Overall, predictive factors were similar when analyzing data from both tools. Predictive factors for the QLQ-C30 were role functioning (p<0.0001), fatigue (p<0.0001), nausea/vomiting (p<0.0001), and financial problems (p<0.0001) and factors for the extracted QLQ-C15-PAL were physical functioning (p<0.0001) and fatigue (p<0.0001). Conclusions: Extraction of the QLQ-C15-PAL items from the QLQ-C30 resulted in similar predictive QOL domains for all patient subgroups analyzed individually. The QLQ-C15-PAL is reflective of the QLQ-C30 domains and is recommended for future studies involving patients in a palliative setting, as this shorter questionnaire reduces patient burden and may increase accrual and compliance, while maintaining a similar breadth of coverage and achieving the same predictive ability. © Copyright 2013, Mary Ann Liebert, Inc.
Authors & Co-Authors
Lam, Kinsey
Canada, Toronto
University of Toronto
Zeng, Liang
Canada, Toronto
University of Toronto
Zhang, Liying
Canada, Toronto
University of Toronto
Tseng, Lingming
Taiwan, Taipei
National Yang-ming University Taiwan
Hou, Mingfeng
Taiwan, Kaohsiung
Kaohsiung Medical University Chung-ho Memorial Hospital
Fairchild, Alysa M.
Canada, Edmonton
Cross Cancer Institute
Vassiliou, Vassilios P.
Cyprus, Nicosia
Bank of Cyprus Group Oncology Centre
Jesus-Garcia, Reynaldo
Brazil, Sao Paulo
Universidade Federal de São Paulo
el-Din, Mohamed Alm
Egypt, Tanta
Tanta University Hospitals
Kumar, Aswin
India, Thiruvananthapuram
Regional Cancer Centre India
Pharmd, Fabien Forges
France, Paris
Inserm
France, Marseille, Saint Etienne
Saint Etienne University Hospital
Chie, Wei-Chu
Taiwan, Taipei
National Taiwan University
Sahgal, Arjun A.
Canada, Toronto
University of Toronto
Poon, Michael
Canada, Toronto
University of Toronto
Chow, Edwardedward L.W.
Canada, Toronto
University of Toronto
Statistics
Citations: 15
Authors: 15
Affiliations: 11
Identifiers
Doi:
10.1089/jpm.2012.0398
ISSN:
10966218
Research Areas
Cancer
Disability
Health System And Policy
Study Design
Cross Sectional Study