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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Circulating inflammatory markers are associated with magnetic resonance imaging-visible perivascular spaces but not directly with white matter hyperintensities
Stroke, Volume 45, No. 2, Year 2014
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Description
Background and Purpose - White matter hyperintensities (WMH) and perivascular spaces (PVS) are features of small vessel disease, found jointly on MRI of older people. Inflammation is a prominent pathological feature of small vessel disease. We examined the association between inflammation, PVS, and WMH in the Lothian Birth Cohort 1936 (N=634). Methods - We measured plasma fibrinogen, C-reactive protein, and interleukin-6 and rated PVS in 3 brain regions. We measured WMH volumetrically and visually using the Fazekas scale. We derived latent variables for PVS, WMH, and Inflammation from measured PVS, WMH, and inflammation markers and modelled associations using structural equation modelling. Results - After accounting for age, sex, stroke, and vascular risk factors, PVS were significantly associated with WMH (β=0.47; P<0.0001); Inflammation was weakly but significantly associated with PVS (β=0.12; P=0.048), but not with WMH (β=0.02; P=NS). Conclusions - Circulating inflammatory markers are weakly associated with MR-visible PVS, but not directly with WMH. Longitudinal studies should examine whether visible PVS predate WMH progression and whether inflammation modulators can prevent small vessel disease. © 2014 American Heart Association, Inc.
Authors & Co-Authors
Aribisala, Benjamin Segun
United Kingdom, Edinburgh
The University of Edinburgh
United Kingdom, Edinburgh
A Platform for Scientific Excellence Sinapse Collaboration
Nigeria, Lagos
Lagos State University
Wiseman, Stewart J.
United Kingdom, Edinburgh
The University of Edinburgh
Morris, Zoe
United Kingdom, Edinburgh
The University of Edinburgh
Valdés-Hernández, Maria Del Carmen
United Kingdom, Edinburgh
The University of Edinburgh
United Kingdom, Edinburgh
A Platform for Scientific Excellence Sinapse Collaboration
Royle, Natalie A.
United Kingdom, Edinburgh
The University of Edinburgh
United Kingdom, Edinburgh
A Platform for Scientific Excellence Sinapse Collaboration
Muñoz Maniega, Susana
United Kingdom, Edinburgh
The University of Edinburgh
United Kingdom, Edinburgh
A Platform for Scientific Excellence Sinapse Collaboration
Gow, Alan J.
United Kingdom, Edinburgh
The University of Edinburgh
United Kingdom, Edinburgh
Heriot-watt University
Corley, Janie
United Kingdom, Edinburgh
The University of Edinburgh
Bastin, Mark E.
United Kingdom, Edinburgh
The University of Edinburgh
United Kingdom, Edinburgh
A Platform for Scientific Excellence Sinapse Collaboration
Starr, John M.
United Kingdom, Edinburgh
The University of Edinburgh
Deary, Ian J.
United Kingdom, Edinburgh
The University of Edinburgh
Wardlaw, Joanna M.
United Kingdom, Edinburgh
The University of Edinburgh
United Kingdom, Edinburgh
A Platform for Scientific Excellence Sinapse Collaboration
Statistics
Citations: 112
Authors: 12
Affiliations: 4
Identifiers
Doi:
10.1161/STROKEAHA.113.004059
ISSN:
00392499
e-ISSN:
15244628
Research Areas
Noncommunicable Diseases
Study Design
Cohort Study