Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Urinary metabolic biomarkers of hepatocellular carcinoma in an Egyptian population: A validation study
Journal of Proteome Research, Volume 10, No. 4, Year 2011
Notification
URL copied to clipboard!
Description
The advent of metabonomics has seen a proliferation of biofluid profiling studies of patients with hepatocellular carcinoma. The majority of these studies have been conducted in single indigenous populations making the widespread applicability of candidate metabolite biomarkers difficult. Presented here is a urinary proton nuclear magnetic resonance spectroscopy study of mainly hepatitis C virus infected Egyptian patients with hepatocellular carcinoma, which corroborates findings of a previous study from our group of mainly hepatitis B-infected Nigerian patients with hepatocellular carcinoma. Using multivariate statistical analysis, in the form of orthogonal signal-corrected partial least squared discriminant analysis, the sensitivity and specificity of the technique for distinguishing patients with tumors from healthy controls and patients with cirrhosis was 100%/94% and 81%/71%, respectively. Discriminatory metabolites included glycine, trimethylamine-N-oxide, hippurate, citrate, creatinine, creatine, and carnitine. This metabolic profile bears similarity to profiles identified in the Nigerian cohort of subjects indicative of tumor effects on physiology, energy production, and aberrant chromosomal methylation. This is the first study to identify similarly altered urine metabolic profiles of hepatocellular carcinoma in two etiologically and ethnically distinct populations, suggesting that altered metabolism as a result of tumorogenesis is independent of these two factors. © 2011 American Chemical Society.
Authors & Co-Authors
Shariff, Mohamed I.F.
United Kingdom, London
Imperial College London
Gomaa, Asmaa Ibrahim
Egypt, Shibin el Kom
Menoufia University
Cox, I. Jane
United Kingdom, London
Foundation for Liver Research
Patel, Madhvi
United Kingdom, London
Imperial College London
Williams, Horace R.T.
United Kingdom, London
Imperial College London
Crossey, Mary M.E.
United Kingdom, London
Imperial College London
Thillainayagam, Andrew V.
United Kingdom, London
Imperial College London
Thomas, Howard C.
United Kingdom, London
Imperial College London
Waked, I. A.
Egypt, Shibin el Kom
Menoufia University
Khan, Shahid A.
United Kingdom, London
Imperial College London
Taylor-Robinson, Simon David
United Kingdom, London
Imperial College London
Statistics
Citations: 90
Authors: 11
Affiliations: 3
Identifiers
Doi:
10.1021/pr101096f
ISSN:
15353893
e-ISSN:
15353907
Research Areas
Cancer
Infectious Diseases
Noncommunicable Diseases
Study Design
Cross Sectional Study
Cohort Study
Study Approach
Quantitative