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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
agricultural and biological sciences
The effect of Sammo administration on some fundamental enzymes of pentose phosphat pathway and energy metabolites of alloxanized rats
Food / Nahrung, Volume 36, No. 1, Year 1992
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Description
Sammo plant which is traditionally used in Egypt for the treatment of diabetes mellitus, was administered at low and high levels (4% and 8% respectively at the expense of starch) to adult male alloxanized albino rats, to study its effect on energy metabolism. Adenosine‐5‐triphosphate (ATP) in the brain (B), liver (L) and kidneys (K) organs of alloxanized rats was significantly lowered compared with the negative control. On the other hand, adenosine‐5‐diphosphate (ADP) and adenosine‐5‐monophosphate (AMP) contents in the same organs were elevated markedly. In this connection myokinase activity in cytoplasmic and mitochondrial fractions of B, L and K organs was stimulated at control. Also, the activities of some fundamental enzymes of the oxidative pentose phosphate pathway i.e. glucose‐6‐phosphate dehydrogenase (G‐6‐PD) and 6‐phospho‐gluconate dehydrogenase (6‐PGD) in cytoplasmic and mitochondrial fractions of the same organs were markedly increased. Administration of Sammo at low and high levels reduced the consumption of ATP in B, L and K organs relative to positive control. Whereas, ADP and AMP contents were relatively reduced. Also, myokinase activity in the same organs were relatively inhibited. The activity of G‐6‐PD and 6‐PGD in cytoplasmic and mitochondrial fractions of the same organs were also decreased relative to the positive control. Copyright © 1992 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim
Authors & Co-Authors
Abdel-Rahim, Emam Mobdy
Egypt, Giza
Faculty of Agriculture
El-Saadany, Said S.
Egypt, Zagazig
Faculty of Agriculture
Abo‐Eytta, A. M.
Egypt, Zagazig
Faculty of Agriculture
Wasi, M. M.
Egypt, Cairo
Nutrition Institute
Statistics
Citations: 35
Authors: 4
Affiliations: 3
Identifiers
Doi:
10.1002/food.19920360103
ISSN:
0027769X
e-ISSN:
15213803
Research Areas
Noncommunicable Diseases
Study Locations
Egypt
Participants Gender
Male