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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
CD4 counts and the risk of systemic non-Hodgkin's lymphoma in individuals with HIV in the UK
Haematologica, Volume 94, No. 6, Year 2009
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Description
Since the introduction of highly active antiretroviral therapy, there has been a decline in the incidence of non-Hodgkin's lymphoma among HIV-infected individuals. We described trends in the incidence of systemic non-Hodgkin's lymphoma in the UK CHIC Study from 1996-2006 and evaluated the association between immunosuppression and development of systemic non-Hodgkin's lymphoma: 286/23,155 (1.2%) individuals developed an AIDS-defining lymphoma (258 systemic). Younger age, receipt of highly active antiretroviral therapy and later calendar year were all independently associated with a reduced risk of systemic non-Hodgkin's lymphoma. A lower latest CD4 count was strongly associated with systemic non-Hodgkin's lymphoma, in patients who had (RR per log 2(cells/mm 3) higher: 0.62) and had not (0.70) received highly active antiretroviral therapy. Associations with other measures of immunosuppression, including nadir CD4 count, experience and duration of severe immunosuppression, were generally weaker. Earlier highly active antiretroviral therapy initiation and wider access to HIV testing is advocated to reduce the risk of systemic non-Hodgkin's lymphoma. ©2009 Ferrata Storti Foundation.
Authors & Co-Authors
Bower, Mark D.
United Kingdom, London
Chelsea and Westminster Hospital
Fisher, Martin J.
United Kingdom, Worthing
University Hospitals Sussex Nhs Foundation Trust
Hill, Teresa
United Kingdom, London
Ucl Medical School
Walsh, John Christopher
United Kingdom, London
Imperial College Healthcare Nhs Trust
Orkin, Chloe
United Kingdom, Worthing
University Hospitals Sussex Nhs Foundation Trust
Phillips, Andrew N.
United Kingdom, London
Ucl Medical School
Bansi-Matharu, Loveleen K.
United Kingdom, London
Ucl Medical School
Gilson, Richard John Cary
United Kingdom, London
Ucl Medical School
Easterbrook, Philippa Jane
United Kingdom, London
Faculty of Life Sciences & Medicine
Johnson, Margaret A.
United Kingdom, London
Royal Free London Nhs Foundation Trust
Gazzard, Brian George L.
United Kingdom, London
Chelsea and Westminster Hospital
Leen, Clifford L.S.
United Kingdom, Edinburgh
Western General Hospital
Morris, Lynn G.
United Kingdom, London
University College London
Schwenk, Achim
United Kingdom, London
North Middlesex University Hospital Nhs Trust
Anderson, Jane
United Kingdom, London
Homerton University Hospital Nhs Foundation Trust
Porter, Kholoud
United Kingdom, London
Medical Research Council
Gompels, Mark M.
United Kingdom, Bristol
North Bristol Nhs Trust
Sabin, Caroline Anne
United Kingdom, London
Ucl Medical School
Statistics
Citations: 55
Authors: 18
Affiliations: 12
Identifiers
Doi:
10.3324/haematol.2008.002691
ISSN:
15928721
Research Areas
Health System And Policy
Infectious Diseases
Study Design
Cohort Study