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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Seasonal and regional dynamics of M. ulcerans transmission in environmental Context: Deciphering the role of water bugs as hosts and vectors
PLoS Neglected Tropical Diseases, Volume 4, No. 7, Article e731, Year 2010
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Description
Background: Buruli ulcer, the third mycobacterial disease after tuberculosis and leprosy, is caused by the environmental mycobacterium M. ulcerans. Various modes of transmission have been suspected for this disease, with no general consensus acceptance for any of them up to now. Since laboratory models demonstrated the ability of water bugs to transmit M. ulcerans, a particular attention is focused on the transmission of the bacilli by water bugs as hosts and vectors. However, it is only through detailed knowledge of the biodiversity and ecology of water bugs that the importance of this mode of transmission can be fully assessed. It is the objective of the work here to decipher the role of water bugs in M. ulcerans ecology and transmission, based on large-scale field studies. Methodology/Principal Findings: The distribution of M. ulcerans-hosting water bugs was monitored on previously unprecedented time and space scales: a total of 7,407 water bugs, belonging to large number of different families, were collected over one year, in Buruli ulcer endemic and non endemic areas in central Cameroon. This study demonstrated the presence of M. ulcerans in insect saliva. In addition, the field results provided a full picture of the ecology of transmission in terms of biodiversity and detailed specification of seasonal and regional dynamics, with large temporal heterogeneity in the insect tissue colonization rate and detection of M. ulcerans only in water bug tissues collected in Buruli ulcer endemic areas. Conclusion/Significance: The large-scale detection of bacilli in saliva of biting water bugs gives enhanced weight to their role in M. ulcerans transmission. On practical grounds, beyond the ecological interest, the results concerning seasonal and regional dynamics can provide an efficient tool in the hands of sanitary authorities to monitor environmental risks associated with Buruli ulcer. © 2010 Marion et al.
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC2897839/bin/pntd.0000731.s001.tif
Authors & Co-Authors
Marion, Estelle
France, Angers
Groupe D'étude Des Interactions Hôte Pathogène
Cameroon, Yaounde
Centre Pasteur du Cameroun
Eyangoh, Sara Irène
Cameroon, Yaounde
Centre Pasteur du Cameroun
Yeramian, Edouard
France, Paris
Institut Pasteur, Paris
Doannio, Julien Marie Christian
Cote D'ivoire, Abidjan
Institut National de Sante Publique Abidjan
Landier, Jordi
France, Paris
Institut Pasteur, Paris
Aubry, Jacques
France, Nantes
Nantes Université
Fontanet, A. L.
France, Paris
Institut Pasteur, Paris
Rogier, Christophe
France, Bretigny-sur-orge
Institut de Recherche Biomédicale Des Armées
Cassisa, Viviane
France, Angers
Groupe D'étude Des Interactions Hôte Pathogène
France, Angers
Chu Angers
Cottin, Jane
France, Angers
Groupe D'étude Des Interactions Hôte Pathogène
France, Angers
Chu Angers
Marot, Agnès
France, Angers
Groupe D'étude Des Interactions Hôte Pathogène
Éveillard, Matthieu
France, Angers
Groupe D'étude Des Interactions Hôte Pathogène
Kamdem, Yannick
Cameroon, Yaounde
Centre Pasteur du Cameroun
Legras, Pierre
France, Angers
Groupe D'étude Des Interactions Hôte Pathogène
France, Angers
Chu Angers
Deshayes, Caroline
France, Angers
Groupe D'étude Des Interactions Hôte Pathogène
Saint-André, Jean Paul
France, Angers
Chu Angers
Marsollier, Laurent
France, Angers
Groupe D'étude Des Interactions Hôte Pathogène
Statistics
Citations: 87
Authors: 17
Affiliations: 7
Identifiers
Doi:
10.1371/journal.pntd.0000731
ISSN:
19352727
e-ISSN:
19352735
Research Areas
Environmental
Genetics And Genomics
Study Locations
Cameroon