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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
The pathological significance of Notch1 in oral squamous cell carcinoma
Laboratory Investigation, Volume 93, No. 10, Year 2013
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Description
Notch signaling has been reported to be involved in several types of malignant tumors; however, the role and activation mechanism of Notch signaling in oral squamous cell carcinoma (OSCC) remains poorly characterized. The purpose of this study was to elucidate the pathological significance of Notch signaling and its activation mechanism in the development and progression of OSCC. In this study, we showed that the expression of Notch1 and intracellular Notch domain (NICD) are upregulated in OSCCs. In addition, Notch1 and NICD were found to be characteristically localized at the invasive tumor front. TNF-α, a major inflammatory cytokine, significantly activated Notch signaling in vitro. In a clinicopathological analysis, Notch1 expression correlated with both the T-stage and the clinical stage. Furthermore, loss of Notch1 expression correlated with the inhibition of cell proliferation and TNF-α-dependent invasiveness in an OSCC cell line. In addition, γ-secretase inhibitor (GSI) prevented cell proliferation and TNF-α-dependent invasion of OSCC cells in vitro. These results indicate that altered expression of Notch1 is associated with increased cancer progression and that Notch1 regulates the steps involved in cell metastasis in OSCC. Moreover, inactivating Notch signaling with GSI could therefore be a useful approach for treating patients with OSCC. © 2013 USCAP.
Authors & Co-Authors
Yoshida, Ryoji
Japan, Kumamoto
Graduate School of Medical Sciences
Nagata, Masashi
Japan, Kumamoto
Graduate School of Medical Sciences
Nakayama, Hideki
Japan, Kumamoto
Graduate School of Medical Sciences
Niimori-Kita, Kanako
Japan, Kumamoto
Graduate School of Medical Sciences
Hassan, Wael Abdo
Japan, Kumamoto
Graduate School of Medical Sciences
Egypt, Ismailia
Faculty of Medicine
Tanaka, Takuji
Japan, Gifu
The Tohkai Cytopathology Institute: Cancer Research and Prevention (tci-carp)
Japan, Kahoku
Kanazawa Medical University
Shinohara, Masanori
Japan, Kumamoto
Graduate School of Medical Sciences
Ito, Takaaki
Japan, Kumamoto
Graduate School of Medical Sciences
Statistics
Citations: 91
Authors: 8
Affiliations: 4
Identifiers
Doi:
10.1038/labinvest.2013.95
ISSN:
00236837
e-ISSN:
15300307
Research Areas
Cancer
Health System And Policy