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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
chemistry
In vivo and in vitro evaluation of highly specific thiolate carrier group copper(II) and zinc(II) complexes on Ehrlich ascites carcinoma tumor model
European Journal of Medicinal Chemistry, Volume 45, No. 11, Year 2010
Notification
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Description
A new series of copper(II) and zinc(II) complexes have been designed and synthesized using a new type of Schiff bases derived from the reaction of 3-(3-phenyl-allylidene)-pentane-2,4-dione with para substituted aniline and benzene-1,2-dithiol. Their structures have been established by analytical and spectral data. The higher ε and low A values together with positive reduction potentials for these copper complexes suggest that they can mimic the functional properties of naturally occurring proteins. In vivo and in vitro antitumor functions of the complexes against Ehrlich ascites carcinoma tumor model have been investigated. The minimum inhibitory concentration of the complexes has also been investigated against Mycobacterium tuberculosis strain H37Rv. These complexes exhibit significant antitumor, cytotoxic and antituberculosis activity. © 2010 Elsevier Masson SAS. All rights reserved.
Authors & Co-Authors
Raman, Natarajan
India, Virudhunagar
Virudhunagar Hindu Nadars' Senthikumara Nadar College
Jeyamurugan, Ramaraj
India, Virudhunagar
Virudhunagar Hindu Nadars' Senthikumara Nadar College
Senthilkumar, Raju
India, Tiruchengode
Swamy Vivekanandha College of Pharmacy, Tiruchengode
Rajkapoor, Balasubramanian
Libya, Sebha
Sebha University
Franzblau, Scott Gary
United States, Chicago
University of Illinois at Chicago
Statistics
Citations: 64
Authors: 5
Affiliations: 4
Identifiers
Doi:
10.1016/j.ejmech.2010.09.004
ISSN:
02235234
e-ISSN:
17683254
Research Areas
Cancer