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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Comprehensive and Integrated Genomic Characterization of Adult Soft Tissue Sarcomas
Cell, Volume 171, No. 4, Year 2017
Notification
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Description
Sarcomas are a broad family of mesenchymal malignancies exhibiting remarkable histologic diversity. We describe the multi-platform molecular landscape of 206 adult soft tissue sarcomas representing 6 major types. Along with novel insights into the biology of individual sarcoma types, we report three overarching findings: (1) unlike most epithelial malignancies, these sarcomas (excepting synovial sarcoma) are characterized predominantly by copy-number changes, with low mutational loads and only a few genes (TP53, ATRX, RB1) highly recurrently mutated across sarcoma types; (2) within sarcoma types, genomic and regulomic diversity of driver pathways defines molecular subtypes associated with patient outcome; and (3) the immune microenvironment, inferred from DNA methylation and mRNA profiles, associates with outcome and may inform clinical trials of immune checkpoint inhibitors. Overall, this large-scale analysis reveals previously unappreciated sarcoma-type-specific changes in copy number, methylation, RNA, and protein, providing insights into refining sarcoma therapy and relationships to other cancer types. Genetic analysis of soft tissue sarcomas shows that they are characterized predominantly by copy-number changes and offers insights into the immune microenviroment to inform clinical trials of checkpoint inhibitors. © 2017 The Authors
Authors & Co-Authors
Adebamowo, Clement
United States, Bethesda
National Institutes of Health Nih
Adebamowo, Sally N.
United States, Bethesda
National Institutes of Health Nih
Akbani, Rehan
United States, Bethesda
National Institutes of Health Nih
Akeredolu, Teniola
United States, Bethesda
National Institutes of Health Nih
Armenia, Joshua
United States, Bethesda
National Institutes of Health Nih
Baker, Laurence H.
United States, Bethesda
National Institutes of Health Nih
Bartlett, John M.S.
United States, Bethesda
National Institutes of Health Nih
Beroukhim, Rameen
United States, Bethesda
National Institutes of Health Nih
Birrer, Michael J.
United States, Bethesda
National Institutes of Health Nih
Bowen, Jay
United States, Bethesda
National Institutes of Health Nih
Bowlby, Reanne
United States, Bethesda
National Institutes of Health Nih
Brooks, Denise B.
United States, Bethesda
National Institutes of Health Nih
Castro, Patricia D.
United States, Bethesda
National Institutes of Health Nih
Cherniack, Andrew D.
United States, Bethesda
National Institutes of Health Nih
Cho, Juok
United States, Bethesda
National Institutes of Health Nih
Chudamani, Sudha
United States, Bethesda
National Institutes of Health Nih
Cooper, Lee Alex Donald
United States, Bethesda
National Institutes of Health Nih
Xu, Jian M.
United States, Bethesda
National Institutes of Health Nih
Dao, Fanny
United States, Bethesda
National Institutes of Health Nih
DeFreitas, Timothy
United States, Bethesda
National Institutes of Health Nih
Delman, Keith A.
United States, Bethesda
National Institutes of Health Nih
Demchok, John A.
United States, Bethesda
National Institutes of Health Nih
DiSaia, Philip John
United States, Bethesda
National Institutes of Health Nih
Drill, Esther N.
United States, Bethesda
National Institutes of Health Nih
Dubina, Michael V.
United States, Bethesda
National Institutes of Health Nih
Felau, Ina
United States, Bethesda
National Institutes of Health Nih
Ferguson, Martin L.
United States, Bethesda
National Institutes of Health Nih
Frazer, Scott
United States, Bethesda
National Institutes of Health Nih
Fronick, Catrina C.
United States, Bethesda
National Institutes of Health Nih
Fulton, Robert S.
United States, Bethesda
National Institutes of Health Nih
Gabriel, Stacey Bolk
United States, Bethesda
National Institutes of Health Nih
Gastier-Foster, Julie M.
United States, Bethesda
National Institutes of Health Nih
Gehlenborg, Nils
United States, Bethesda
National Institutes of Health Nih
Getz, Gad A.
United States, Bethesda
National Institutes of Health Nih
Godwin, Andrew K.
United States, Bethesda
National Institutes of Health Nih
Grilley-Olson, Juneko E.
United States, Bethesda
National Institutes of Health Nih
Gutman, David A.
United States, Bethesda
National Institutes of Health Nih
Hegde, Apurva M.
United States, Bethesda
National Institutes of Health Nih
Heiman, David I.
United States, Bethesda
National Institutes of Health Nih
Hoadley, Katherine A.
United States, Bethesda
National Institutes of Health Nih
Huang, Mei
United States, Bethesda
National Institutes of Health Nih
Hutter, Carolyn M.
United States, Bethesda
National Institutes of Health Nih
Ittmann, Michael M.
United States, Bethesda
National Institutes of Health Nih
Jones, Corbin D.
United States, Bethesda
National Institutes of Health Nih
Jones, Steven J.M.
United States, Bethesda
National Institutes of Health Nih
Karlan, Beth Y.
United States, Bethesda
National Institutes of Health Nih
Kim, Jaegil
United States, Bethesda
National Institutes of Health Nih
Laird, Peter W.
United States, Bethesda
National Institutes of Health Nih
Lawrence, Michael S.
United States, Bethesda
National Institutes of Health Nih
Lazar, A. J.
United States, Bethesda
National Institutes of Health Nih
Lee, Sanghoon
United States, Bethesda
National Institutes of Health Nih
Lehmann, Kjong Van
United States, Bethesda
National Institutes of Health Nih
Lester, Jenny
United States, Bethesda
National Institutes of Health Nih
Levine, Douglas A.
United States, Bethesda
National Institutes of Health Nih
Lichtenberg, Tara M.
United States, Bethesda
National Institutes of Health Nih
Lin, Pei
United States, Bethesda
National Institutes of Health Nih
Liu, Jia
United States, Bethesda
National Institutes of Health Nih
Liu, Wenbin
United States, Bethesda
National Institutes of Health Nih
Lolla, Laxmi
United States, Bethesda
National Institutes of Health Nih
Lu, Yiling
United States, Bethesda
National Institutes of Health Nih
Ma, Yussanne P.
United States, Bethesda
National Institutes of Health Nih
Magliocco, Anthony Martin
United States, Bethesda
National Institutes of Health Nih
Manikhas, Georgiy Moiseevich
United States, Bethesda
National Institutes of Health Nih
Mardis, Elaine R.
United States, Bethesda
National Institutes of Health Nih
Marra, Marco A.
United States, Bethesda
National Institutes of Health Nih
Martignetti, John A.
United States, Bethesda
National Institutes of Health Nih
Meier, Samuel R.
United States, Bethesda
National Institutes of Health Nih
Mills, Gordon B.
United States, Bethesda
National Institutes of Health Nih
Moore, Richard A.
United States, Bethesda
National Institutes of Health Nih
Mungall, Andrew J.
United States, Bethesda
National Institutes of Health Nih
Mungall, Karen L.
United States, Bethesda
National Institutes of Health Nih
Naresh, Rashi
United States, Bethesda
National Institutes of Health Nih
Newton, Yulia
United States, Bethesda
National Institutes of Health Nih
Noble, Michael S.
United States, Bethesda
National Institutes of Health Nih
Owonikoko, Taofeek Kunle
United States, Bethesda
National Institutes of Health Nih
Parker, Joel S.
United States, Bethesda
National Institutes of Health Nih
Paulauskis, Joseph D.
United States, Bethesda
National Institutes of Health Nih
Pihl, Todd D.
United States, Bethesda
National Institutes of Health Nih
Pollock, Raphael E.
United States, Bethesda
National Institutes of Health Nih
Radenbaugh, Amie J.
United States, Bethesda
National Institutes of Health Nih
Ramalingam, Suresh S.
United States, Bethesda
National Institutes of Health Nih
Ramirez, Nilsa C.
United States, Bethesda
National Institutes of Health Nih
Reynolds, Sheila M.
United States, Bethesda
National Institutes of Health Nih
Roach, Jeffrey M.
United States, Bethesda
National Institutes of Health Nih
Robertson, Andrew Gordon
United States, Bethesda
National Institutes of Health Nih
Roszik, Janos
United States, Bethesda
National Institutes of Health Nih
Rubin, Brian P.
United States, Bethesda
National Institutes of Health Nih
Saksena, Gordon
United States, Bethesda
National Institutes of Health Nih
Sánchez-Vega, Francisco
United States, Bethesda
National Institutes of Health Nih
Schein, Jacqueline E.
United States, Bethesda
National Institutes of Health Nih
Schultz, Nikolaus D.
United States, Bethesda
National Institutes of Health Nih
Schumacher, Steven E.
United States, Bethesda
National Institutes of Health Nih
Sekhon, Harman S.
United States, Bethesda
National Institutes of Health Nih
Shen, Ronglai
United States, Bethesda
National Institutes of Health Nih
Shmulevich, Ilya
United States, Bethesda
National Institutes of Health Nih
Sofia, Heidi J.
United States, Bethesda
National Institutes of Health Nih
Sun, Qiang
United States, Bethesda
National Institutes of Health Nih
Tarnuzzer, Roy W.
United States, Bethesda
National Institutes of Health Nih
van de Rijn, Matt
United States, Bethesda
National Institutes of Health Nih
van den Berg, David J.
United States, Bethesda
National Institutes of Health Nih
Van Tine, Brian A.
United States, Bethesda
National Institutes of Health Nih
Verhaak, Roel G.W.
United States, Bethesda
National Institutes of Health Nih
Voet, Doug
United States, Bethesda
National Institutes of Health Nih
Wan, Yunhu
United States, Bethesda
National Institutes of Health Nih
Wang, Jing
United States, Bethesda
National Institutes of Health Nih
Wilkerson, Matthew D.
United States, Bethesda
National Institutes of Health Nih
Wilson, Richard K.
United States, Bethesda
National Institutes of Health Nih
Wrangle, John M.
United States, Bethesda
National Institutes of Health Nih
Wu, Ye
United States, Bethesda
National Institutes of Health Nih
Yau, Christina
United States, Bethesda
National Institutes of Health Nih
Zenklusen, Jean Claude
United States, Bethesda
National Institutes of Health Nih
Zhang, Hailei
United States, Bethesda
National Institutes of Health Nih
Zmuda, Erik J.
United States, Bethesda
National Institutes of Health Nih
Statistics
Citations: 586
Authors: 113
Affiliations: 1
Identifiers
Doi:
10.1016/j.cell.2017.10.014
ISSN:
00928674
Research Areas
Cancer
Genetics And Genomics
Health System And Policy