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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Synthesis of I-131 labelled 4-iodophenylacetic acid
Journal of Labelled Compounds and Radiopharmaceuticals, Volume 54, No. 1, Year 2011
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Description
Phenylacetate has been reported to have a potent anti-proliferative and anti-differentiating effect in haematological malignancies and in solid tumours at non-toxic concentrations. This study is a preliminary investigation into the potential of 4-iodophenylacetic acid radiolabelled by 131I as a radiopharmaceutical equivalent. The radiolabelling by isotope exchange gave a radiochemical yield of 53±6%, and a radiochemical purity of 97.8±1.2% as qualified by HPLC. The product contained 4% ester by-product and is suitable for studies in animals. © 2010 John Wiley & Sons, Ltd.
Authors & Co-Authors
Szücs, Z.
South Africa, Pretoria
Necsa
Sathekge, Mike Machaba
South Africa, Pretoria
Steve Biko Academic Hospital
Marjanovic-Painter, Biljana
South Africa, Pretoria
Necsa
Wagener, Judith Marie
South Africa, Pretoria
Necsa
Sello, Thato S.
South Africa, Pretoria
Necsa
Wagener, Carl
South Africa, Pretoria
Necsa
Zeevaart, Jan Rijn
South Africa, Potchefstroom
North-west University
Statistics
Citations: 7
Authors: 7
Affiliations: 3
Identifiers
Doi:
10.1002/jlcr.1812
ISSN:
03624803
e-ISSN:
10991344
Research Areas
Environmental