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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Highly active antiretroviral therapies among HIV-1-infected children in Abidjan, Côte d'Ivoire
AIDS, Volume 18, No. 14, Year 2004
Notification
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Description
Objective: To describe the effect of highly active antiretroviral therapy (HAART) in HIV-1-infected African children. Study design: Observational ANRS 1244 cohort of 159 children with HIV between October 2000 and September 2002; 78 children (49%) receiving HAART were followed for a mean duration of 21 months. Methods: Weight-for-age Z-scores (WAZ), height-for-age Z-scores (HAZ), CD4 lymphocyte count and HIV-1 RNA viral load were measured before initiating HAART and every 6 months during treatment. Probability of survival and incidences of pneumonia and acute diarrhoea were calculated. Results: Values before and after 620 days of HAART, respectively, were -2.02 and -1.39 for mean WAZ, (P < 0.01); -2.03 and -1.83 for mean HAZ (P = 0.51); 0.07 and 0.025/child-month (P = 0.002) for incidence of pneumonia; and 0.12 and 0.048/ child-month for incidence of acute diarrhoea (P < 0.001) (incidence changes statistically significant only in children < 6.5 years). Overall, the probability of survival under HAART was 72.8% at 24 months for children with < 5% CD4 cells versus 97.8% in children with ≥ 5% (P < 0.01). At HAART initiation, median viral load and CD4 cell percentage were 5.41 log10 copies/ml and 7.7%, respectively. After 756 days of HAART, on average, 50% of patients had undetectable viral load and 10% had 2.4-3.0 log10 copies/ml. The median CD4 percentage was 22.5%. Conclusion: In resource-limited setting, it is possible to use HAART to treat African children. This treatment appears as effective as in developed countries. © 2004 Lippincott Williams & Wilkins.
Authors & Co-Authors
Fassinou, Patricia
Unknown Affiliation
Elenga, Narcisse
Unknown Affiliation
Rouet, François
Unknown Affiliation
Laguide, Rockiath
Unknown Affiliation
Kouakoussui, Kouakou Alain
Unknown Affiliation
Timité, Marguerite
Unknown Affiliation
Blanche, Stéphane
France, Paris
Hôpital Necker Enfants Malades
Msellati, Philippe
France, Montpellier
Ird Centre de Montpellier
France, Marseille
Ird Institut de Recherche Pour le Developpement
Statistics
Citations: 176
Authors: 8
Affiliations: 3
Identifiers
Doi:
10.1097/00002030-200409240-00006
ISSN:
02699370
Research Areas
Infectious Diseases
Maternal And Child Health
Study Design
Cohort Study
Study Locations
Ivory Coast