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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Addressing continuous data measured with different instruments for participants excluded from trial analysis: A guide for systematic reviewers
Journal of Clinical Epidemiology, Volume 67, No. 5, Year 2014
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Description
Background We previously developed an approach to address the impact of missing participant data in meta-analyses of continuous variables in trials that used the same measurement instrument. We extend this approach to meta-analyses including trials that use different instruments to measure the same construct. Methods We reviewed the available literature, conducted an iterative consultative process, and developed an approach involving a complete-case analysis complemented by sensitivity analyses that apply a series of increasingly stringent assumptions about results in patients with missing continuous outcome data. Results Our approach involves choosing the reference measurement instrument; converting scores from different instruments to the units of the reference instrument; developing four successively more stringent imputation strategies for addressing missing participant data; calculating a pooled mean difference for the complete-case analysis and imputation strategies; calculating the proportion of patients who experienced an important treatment effect; and judging the impact of the imputation strategies on the confidence in the estimate of effect. We applied our approach to an example systematic review of respiratory rehabilitation for chronic obstructive pulmonary disease. Conclusions Our extended approach provides quantitative guidance for addressing missing participant data in systematic reviews of trials using different instruments to measure the same construct. © 2014 Elsevier Inc. All rights reserved.
Authors & Co-Authors
Ebrahim, Shanil
Canada, Hamilton
Mcmaster University
United States, Stanford
Stanford University School of Medicine
Canada, Toronto
Hospital for Sick Children University of Toronto
Johnston, Bradley C.
Canada, Hamilton
Mcmaster University
Canada, Toronto
Hospital for Sick Children University of Toronto
Canada, Toronto
Sickkids Research Institute
Canada, Toronto
Institute of Health Policy, Management and Evaluation
Akl, Elie A.
Canada, Hamilton
Mcmaster University
Lebanon, Beirut
American University of Beirut
United States, Buffalo
Jacobs School of Medicine and Biomedical Sciences
Mustafa, Reem A.
Canada, Hamilton
Mcmaster University
United States, Kansas City
University of Missouri-kansas City
Sun, Xin
Canada, Hamilton
Mcmaster University
China, Chongqing
Xinqiao Hospital
Walter, Stephen D.
Canada, Hamilton
Mcmaster University
Heels-Ansdell, Diane M.
Canada, Hamilton
Mcmaster University
Alonso-Coello, Pablo
Canada, Hamilton
Mcmaster University
Spain, Madrid
Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública
Gordon, Guyatt H.
Canada, Hamilton
Mcmaster University
Statistics
Citations: 65
Authors: 9
Affiliations: 10
Identifiers
Doi:
10.1016/j.jclinepi.2013.11.014
ISSN:
08954356
e-ISSN:
18785921
Research Areas
Disability
Study Design
Quasi Experimental Study
Study Approach
Quantitative
Systematic review