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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
A randomized controlled pilot trial of azithromycin or artesunate added to sulfadoxine-pyrimethamine as treatment for malaria in pregnant women
PLoS ONE, Volume 2, No. 11, Article e1166, Year 2007
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Description
Objective. New anti-malarial regimens are urgently needed in sub-Saharan Africa because of the increase in drug resistance. We investigated the safety and efficacy of azithromycin or artesunate combined with sulfadoxine-pyrimethamine used for treatment of malaria in pregnant women in Blantyre, Malawi. Methods/Findings. This was a randomized open-label clinical trial, conducted at two rural health centers in Blantyre district, Malawi. A total of 141 pregnant women with uncompicated Plasmodium falciparum malaria were recruited and randomly allocated to 3 treatment groups: sulfadoxine-pyrimethamine (SP; 3 tablets, 500 mg sulfadoxine and 25 mg pyrimethamine per tablet); SP plus azithromycin (1 g/day x2 days); or SP plus artesunate (200 mg/dayx3 days). Women received two doses administered at least 4 weeks apart. Heteroduplex tracking assays were performed to distinguish recrudescence from new infections. Main outcome measures were incidence of adverse outcomes, parasite and fever clearance times and recrudescence rates. All treatment regimens were well tolerated. Two women vomited soon after ingesting azithromycin. The parasite clearance time was significantly faster in the SP-artesunate group. Recrudescent episodes of malaria were less frequent with SP-azithromycin [Hazard Ratio 0.19 (95% confidence interval 0.06 to 0.63)] and SP-artesunate [Hazard Ratio 0.25 (95% confidence interval 0.10 to 0.65)] compared with SP monotherapy. With one exception (an abortion in the SP-azithromycin group), all adverse pregnancy outcomes could be attributed to known infectious or obstetrical causes, Because of the small sample size, the effect on birth outcomes, maternal malaria or maternal anemia could not be evaluated. Conclusions. Both SP-artesunate and SP-azithromycin appeared to be safe, well tolerated and efficacious for the treatment of malaria during pregnancy. A larger study is needed to determine their safety and efficacy in preventing poor birth outcomes. © 2007 Kalilani et al.
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC2048661/bin/pone.0001166.s001.doc
https://efashare.b-cdn.net/share/pmc/articles/PMC2048661/bin/pone.0001166.s002.doc
Authors & Co-Authors
Kalilani-Phiri, Linda V.
United States, Chapel Hill
The University of North Carolina at Chapel Hill
Mofolo, Innocent A.
Malawi, Zomba
University of Malawi
Chaponda, Marjorie
Malawi, Zomba
University of Malawi
Rogerson, Stephen J.
Australia, Melbourne
University of Melbourne
Alker, Alisa P.
United States, Chapel Hill
The University of North Carolina at Chapel Hill
Kwiek, Jesse J.
United States, Chapel Hill
The University of North Carolina at Chapel Hill
Meshnick, Steven Richard
United States, Chapel Hill
The University of North Carolina at Chapel Hill
Statistics
Citations: 73
Authors: 7
Affiliations: 3
Identifiers
Doi:
10.1371/journal.pone.0001166
e-ISSN:
19326203
Research Areas
Environmental
Infectious Diseases
Maternal And Child Health
Sexual And Reproductive Health
Study Design
Cohort Study
Study Locations
Malawi
Participants Gender
Female