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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Impairment of cardiac function in hypertensive patients with Type 2 diabetes: A LIFE study
Diabetic Medicine, Volume 22, No. 8, Year 2005
Notification
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Description
Aims: Type 2 diabetic patients with hypertension have an increased left ventricular (LV) mass and impaired cardiac function compared to hypertensive patients without diabetes. However, it is unknown if the impaired cardiac function can be explained solely by LV hypertrophy, or is independently related to diabetes. The aim of the present study was to compare LV function between diabetic and non-diabetic hypertensive patients with electrocardiographic LV hypertrophy. Methods: In 937 patients participating in the LIFE echocardiographic sub-study, all echocardiograms were centrally evaluated by a core reading centre measuring LV mass, systolic and diastolic LV function. Known diabetes was present in 105 patients. Results: Left ventricular mass was similar in diabetic and non-diabetic patients. Endocardial systolic LV function, estimated by LV ejection fraction, was reduced and indices of midwall systolic LV function were impaired in the diabetic patients. Diastolic LV filling pattern was impaired and arterial stiffness, measured by pulse pressure/stroke index, was increased in diabetic patients. Conclusions: Systolic and diastolic LV function in hypertensive patients with electrocardiographic LV hypertrophy and diabetes are impaired independent of LV mass, most likely reflecting the adverse effects of diabetes per se. © 2005 Diabetes UK.
Authors & Co-Authors
Hildebrandt, Per Rossen
Denmark, Copenhagen
Frederiksberg Hospital
Wachtell, Kristian
Denmark, Glostrup
Amtssygehuset I Glostrup
United States, New York
Weill Cornell Medicine
Dahlof̈, Björn L.
Sweden, Gothenburg
Sahlgrenska Universitetssjukhuset
Giles, Thomas D.
United States, New Orleans
Lsuhsc School of Medicine
Olsen, Michael Hecht
Denmark, Glostrup
Amtssygehuset I Glostrup
Devereux, Richard Blyton
United States, New York
Weill Cornell Medicine
Statistics
Citations: 11
Authors: 6
Affiliations: 8
Identifiers
Doi:
10.1111/j.1464-5491.2005.01564.x
ISSN:
07423071
Research Areas
Noncommunicable Diseases