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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
pharmacology, toxicology and pharmaceutics
Light-and melanin nanoparticle-induced cytotoxicity in metastatic cancer cells
Pharmaceutics, Volume 13, No. 7, Article 965, Year 2021
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Description
Melanin nanoparticles are known to be biologically benign to human cells for a wide range of concentrations in a high glucose culture nutrition. Here, we show cytotoxic behavior at high na-noparticle and low glucose concentrations, as well as at low nanoparticle concentration under exposure to (nonionizing) visible radiation. To study these effects in detail, we developed highly mon-odispersed melanin nanoparticles (both uncoated and glucose-coated). In order to study the effect of significant cellular uptake of these nanoparticles, we employed three cancer cell lines: VM-M3, A375 (derived from melanoma), and HeLa, all known to exhibit strong macrophagic character, i.e., strong nanoparticle uptake through phagocytic ingestion. Our main observations are: (i) metastatic VM-M3 cancer cells massively ingest melanin nanoparticles (mNPs); (ii) the observed ingestion is enhanced by coating mNPs with glucose; (iii) after a certain level of mNP ingestion, the metastatic cancer cells studied here are observed to die—glucose coating appears to slow that process; (iv) cells that accumulate mNPs are much more susceptible to killing by laser illumination than cells that do not accumulate mNPs; and (v) non-metastatic VM-NM1 cancer cells also studied in this work do not ingest the mNPs, and remain unaffected after receiving identical optical energy levels and doses. Results of this study could lead to the development of a therapy for control of metastatic stages of cancer. © 2021 by the authors. Licensee MDPI, Basel, Switzerland.
Authors & Co-Authors
Mukherjee, Purna
United States, Chestnut Hill
Boston College
Seyfried, Thomas N.
United States, Chestnut Hill
Boston College
Nwaji, Njemuwa Njoku
China, Guangzhou
South China Normal University
Akinoglu, Eser Metin
China, Guangzhou
South China Normal University
Zhou, Guofu
China, Guangzhou
South China Normal University
Statistics
Citations: 4
Authors: 5
Affiliations: 4
Identifiers
Doi:
10.3390/pharmaceutics13070965
ISSN:
19994923
Research Areas
Cancer
Food Security