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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Platelet and erythrocyte mg
2+
, ca
2+
, na
+
, k
+
and cell membrane adenosine triphosphatase activity in essential hypertension in blacks
Journal of Hypertension, Volume 10, No. 6, Year 1992
Notification
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Description
Objective: To assess the relationship between intracellular Mg2+, Ca2+, Na+ and K+and cell membrane adenosine triphosphatase (ATPase) activity in normotensive and hypertensive blacks. Design: Intracellular cations and cell membrane ATPase activity were studied in black patients with untreated essential hypertension and age-, weight- and height-matched normotensive controls. Platelet, erythrocyte and serum Mg2+, Ca2+, Na+ and K+levels as well as platelet and erythrocyte membrane Na+, K+ -ATPase, Ca2+-ATPase and Mg2+-ATPase activities were measured in all subjects. Methods: Intracellular Na+ and K+ were measured by flame photometry and Mg+and Ca+ by atomic absorption spectrophotometry. Cell membrane ATPase activity was determined by a colorimetric method. Results: The hypertensive group consistently demonstrated depressed activity of each ATPase studied, with significantly lower serum Mg2+, serum K+, erythrocyte Mg2+and platelet Mg2+ levels compared with the normotensive group. Platelet Na+ and Ca2+ and erythrocyte Ca2+ were significantly elevated in the hypertensive group. In the hypertensive group, mean arterial pressure (MAP) was inversely correlated with platelet and erythrocyte membrane Na+, K+-ATPase, Ca2+-ATPase and Mg2+-ATPase. Serum Mg2+, serum Ca2+ and platelet Mg2+ were negatively correlated with MAP in the hypertensive group whilst erythrocyte and platelet Ca2+ were positively correlated. In the normotensive group, platelet Mg2+ and MAP were negatively, and erythrocyte Ca2+ and MAP, positively correlated. Conclusions: Black patients with essential hypertension have widespread depression of cell membrane Na+, K+-ATPase, Ca2+ -ATPase and Mg2+-ATPase activities with serum and intracellular Mg2+ depletion and cytosolic Na+ and Ca2+ overload, which may reflect an underlying membrane abnormality in essential hypertension. These cellular abnormalities may be related to the defective transport mechanisms that in turn may be aggravated by Mg2+ depletion. © Current Science Ltd.
Authors & Co-Authors
Touyz, Rhian M.
South Africa, Johannesburg
School of Clinical Medicine
Milne, Frank John
South Africa, Johannesburg
School of Clinical Medicine
Reinach, Stefan G.
South Africa, Tygerberg
South African Medical Research Council
Statistics
Citations: 38
Authors: 3
Affiliations: 2
Identifiers
Doi:
10.1097/00004872-199206000-00010
ISSN:
02636352
e-ISSN:
14735598
Research Areas
Mental Health
Noncommunicable Diseases