Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
At least five polymorphic mutants account for the prevalence of glucose-6-phosphate dehydrogenase deficiency in Algeria
Human Genetics, Volume 94, No. 5, Year 1994
Notification
URL copied to clipboard!
Description
The electrophoretic mobility and level of enzyme activity of glucose-6-phosphate dehydrogenase (G6PD) was established in 100 unrelated Algerian males with G6PD deficiency. DNA from these subjects was analysed for the presence of certain known G6PD mutations by the appropriate restriction enzyme digestion of fragments amplified by the polymerase chain reaction. Where the mutation could not be identified in this way, the samples were subjected to single-strand conformation polymorphism analysis and abnormal fragments were sequenced. In this way, eight different mutations have been identified, of which five are polymorphic and account for 92% of the samples. The most common variants are G6PD A-(46%) and G6PD Mediterranean (23%), both of which were associated with favism. A new polymorphic variant, G6PD Aures, has been identified during the course of this study, whereas another, G6PD Santamaria, has now been established as a polymorphic variant (11%). Thus, G6PD deficiency in Algeria is heterogeneous, suggesting that there has been significant gene flow, both from sub-Saharan Africa and from other parts of the Mediterranean. © 1994 Springer-Verlag.
Authors & Co-Authors
Nafa, Khédoudja
Algeria, Algiers
Centre Hospitalo-universitaire de Mustapha Bacha
United Kingdom, London
Ucl Cancer Institute
Reghis, Abderrezak
Algeria, Algiers
Centre Hospitalo-universitaire de Mustapha Bacha
Osmani, Naima
Algeria, Algiers
Centre Hospitalo-universitaire de Mustapha Bacha
Baghli, Lamia
Algeria, Algiers
Centre Hospitalo-universitaire de Mustapha Bacha
Aït-Abbes, Hassen
Algeria, Algiers
Centre Hospitalo-universitaire de Mustapha Bacha
Benabadji, Mohamed
Algeria, Algiers
Centre Hospitalo-universitaire de Mustapha Bacha
Kaplan, Jean Claude
France, Paris
Hopital Cochin Ap-hp
Vulliamy, Tom J.
United Kingdom, London
Ucl Cancer Institute
Luzzatto, Lucio
United Kingdom, London
Ucl Cancer Institute
Statistics
Citations: 31
Authors: 9
Affiliations: 3
Identifiers
Doi:
10.1007/BF00211017
ISSN:
03406717
e-ISSN:
14321203
Research Areas
Cancer
Genetics And Genomics
Study Design
Cross Sectional Study
Study Locations
Algeria