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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Integrated morphologic and functional assessment of the aortic root after different tissue valve root replacement procedures
Journal of Thoracic and Cardiovascular Surgery, Volume 143, No. 6, Year 2012
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Description
Objectives: This study was undertaken to explore aspects of the hemodynamic function of different biologic tissue aortic valve root replacements. We set out to image and display the spatiotemporal distributions of axially directed blood velocity through the aortic root. Methods: The flow velocities through a plane transecting the aortic root were measured by 2-dimensional cine phase-contrast magnetic resonance velocity mapping in 44 subjects: 29 patients who had undergone aortic root replacement approximately 10 years previously (13 autografts, 10 stentless xenografts, and 6 homografts) and 15 healthy control subjects. With cine as well as velocity images, aortic sinus dimensions, effective orifice area, and several velocity parameters were measured. Color-coded plots of velocity relative to the sinus cross sections and velocity-time plots were used to compare spatiotemporal distributions of velocity. Results: Peak flow velocity was similar between the autografts (102 ± 28.0 cm/s) and control valves (119 ± 20.0 cm/s) but was higher in xenografts (167 ± 36.0 cm/s) and homografts (206 ± 91.0 cm/s). These measurements showed an inverse relationship with the effective orifice area (7.27 ± 0.20, 4.24 ± 0.81, 3.37 ± 0.32, and 3.28 ± 0.87 cm2, respectively). Autograft peak flow velocity showed no significant difference from control valve peak flow velocity, despite larger root dimensions (P < .001). The graphic displays provided further spatiotemporal information. Conclusions: Peak velocities and spatiotemporal flow patterns depend on the type of valve substitute. In the parameters measured, autograft replacements differed least from normal aortic valves. Copyright © 2012 by The American Association for Thoracic Surgery.
Authors & Co-Authors
Torii, Ryo
Qatar, Doha
Qatar Cardiovascular Research Center
United Kingdom, Harefield
Harefield Hospital
United Kingdom, London
Imperial College London
El-Hamamsy, Ismail
United Kingdom, Harefield
Harefield Hospital
Donya, Mohamed
Egypt, Aswan
Aswan Heart Centre
Babu-Narayan, Sonya Vidya
United Kingdom, London
Royal Brompton Hospital
Ibrahim, Michael E.K.
United Kingdom, Harefield
Harefield Hospital
Kilner, Philip John
United Kingdom, London
Royal Brompton Hospital
Mohiaddin, Raad H.
United Kingdom, London
Royal Brompton Hospital
Xu, Xiao Yun
United Kingdom, London
Imperial College London
Yacoub, Magdi H.
Qatar, Doha
Qatar Cardiovascular Research Center
United Kingdom, Harefield
Harefield Hospital
Statistics
Citations: 36
Authors: 9
Affiliations: 5
Identifiers
Doi:
10.1016/j.jtcvs.2011.12.034
ISSN:
00225223
e-ISSN:
1097685X
Research Areas
Health System And Policy