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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Nutritional deficiencies and clinical correlates in first-episode psychosis: A systematic review and meta-analysis
Schizophrenia Bulletin, Volume 44, No. 6, Year 2018
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Description
Objective: Diet is increasingly recognized as a potentially modifiable factor influencing the onset and outcomes of psychiatric disorders. Whereas, previous research has shown long-term schizophrenia is associated with various nutritional deficiencies, this meta-analysis aimed to determine the prevalence and extent of nutritional deficits in first-episode psychosis (FEP). Method: A search of electronic databases conducted in July 2017 identified 28 eligible studies, examining blood levels of 6 vitamins and 10 minerals across 2612 individuals: 1221 individuals with FEP and 1391 control subjects. Meta-analyses compared nutrient levels in FEP to nonpsychiatric controls. Clinical correlates of nutritional status in patient samples were systematically reviewed. Results: Significantly lower blood levels of folate (N = 6, n = 827, g =-0.624, 95% confidence interval [CI] =-1.176 to-0.072, P = .027) and Vitamin D (N = 7, n = 906, g =-1.055, 95% CI =-1.99 to-0.119, P = .027) were found in FEP compared to healthy controls. Synthesis of clinical correlates found both folate and Vitamin D held significant inverse relationships with psychiatric symptoms in FEP. There was also limited evidence for serum level reductions of Vitamin C (N = 2, n = 96, g =-2.207, 95% CI =-3.71 to-0.71, P = .004). No differences were found for other vitamins or minerals. Conclusions: Deficits in Vitamin D and folate previously observed in long-term schizophrenia appear to exist from illness onset, and are associated with worse symptomology. Further research must examine the direction and nature of these relationships (ie, mediator, moderator, or marker) with clinical status in FEP. Future trials assessing efficacy of nutrient supplementation in FEP samples should consider targeting and stratifying for baseline deficiency. © The Author(s) 2017.
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC6192507/bin/sbx162_suppl_supplement_1.doc
https://efashare.b-cdn.net/share/pmc/articles/PMC6192507/bin/sbx162_suppl_supplement_2.doc
Authors & Co-Authors
Firth, Joseph
Australia, Penrith
Western Sydney University
United Kingdom, Manchester
Faculty of Biology, Medicine and Health
Stubbs, Brendon
United Kingdom, London
South London and Maudsley Nhs Foundation Trust
United Kingdom, London
King's College London
Vancampfort, Davy
Belgium, Leuven
Departement Revalidatiewetenschappen
Belgium, Leuven
Ku Leuven
Ward, Philip B.
Australia, Kensington
University of new South Wales Faculty of Medicine, School of Psychiatry
Australia, Liverpool
Ingham Institute for Applied Medical Research
Berk, Michael
Australia, Geelong
Deakin University
Australia, Melbourne
The Florey
Australia, Melbourne
Orygen Youth Health
Sarris, Jerome
Australia, Penrith
Western Sydney University
Australia, Melbourne
University of Melbourne
Statistics
Citations: 60
Authors: 6
Affiliations: 13
Identifiers
Doi:
10.1093/schbul/sbx162
ISSN:
05867614
Research Areas
Health System And Policy
Mental Health
Study Design
Cross Sectional Study
Study Approach
Systematic review